MutSγ-Induced DNA Conformational Changes Provide Insights into its Role in Meiotic Recombination

In many organisms, MutSγ plays a role in meiotic recombination facilitating crossover formation between homologous chromosomes. Failure to form crossovers leads to improper segregation of chromosomes and aneuploidy, which in humans results in infertility and birth defects. To improve current understanding of MutSγ function, this study investigates the binding affinities and structures of MutSγ in complex with DNA substrates that model homologous recombination intermediates. For these studies we overexpressed and isolated from E.

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