Conformations of an RNA Helix-Junction-Helix Construct revealed by SAXS Refinement of MD Simulations

Ribonucleic acid (RNA) is involved in a broad range of biological processes that extend far beyond translation. Many of RNAs recently discovered functions rely on folding to a specific conformation or transitioning between conformations. RNA structure contains rigid, short base-paired regions connected by more flexible linkers. Studies of model constructs such as small helix-junction-helix (HJH) motifs are useful in understanding how these elements work together to determine RNA conformation. Here, we reveal the full ensemble of solution structures assumed by a model RNA HJH.

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