Resting frontal EEG asymmetry in adolescents with major depression: impact of disease state and comorbid anxiety disorder

Major Depression (MD) is a severe mental disorder with lifetime prevalence rates of 17% (Kessler et al., 2005), mostly beginning between the ages of 12-18 years (Zisook et al., 2007). Up to 75% of children and adolescents with MD are affected by a depressive disorder as adults (Fombonne et al., 2001). Apart from the well-known diagnostic symptoms such as depressive mood (American Psychiatric Association, 2013), MD is also associated with abnormal approach and withdrawal tendencies (Derntl et al., 2011; Radke et al., 2014), which are reflected in aberrant cognition and behavior, such as e.g.

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