Characteristics and Outcomes of Liver Transplantation for Primary Biliary Cholangitis (PBC) in Young patients: Analysis of the United Network for Organ Sharing Database

Background Primary biliary cholangitis (PBC) in younger patients has been suggested to require liver transplantation (LT) in early adulthood, but data is limited on its outcomes. We aimed to evaluate the characteristics and outcome of LT in young patients with PBC in comparison with older adults. Methods The United Network for Organ Sharing (UNOS) database was analyzed for all patients with PBC who underwent LT between 2000 and 2012. Based on age at the time of LT subjects were divided into two groups: young patients (≤ 40 years) and older adults (≥ 41 years). Baseline demographics, clinical parameters, and outcomes of LT were then compared between the two groups. Univariable and multivariable analyses were performed to assess the factors associated with outcomes of LT. Results A total of 2,084 patients with PBC were included in the analysis with 158 young patients. Compared to older adults, younger patients were more likely to be male (27.2% vs. 15.4%) and non-white (43.7% vs. 21.5%) but they were less likely to have obesity, diabetes, or hypertension (p

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