B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

Initiation of CD4+ T cell response depends on antigen-presenting cells. Contrary to the paradigm that dendritic cells are required for this process, Hong et al. show that antigen-specific B cells are essential and sufficient to activate naive CD4+ T cells in response to virus-like particles or influenza vaccination.

https://ift.tt/2Nimitm