Tumor control probability analysis for single fraction carbon ion radiotherapy of early-stage non-small cell lung cancer

The suitability of the LQ and USC models to accurately forecast the 3-year local control rate of early stage NSCLC after CIRT is investigated in this study. The results suggest that the USC model is more appropriate in predicting the single fraction clinical outcome. However, for the 4, 9 and 18 fractionation schedules, the LQ and USC models predicted comparable local control rates. An USC-based SOBP was then developed, providing a better clinical dose estimate for optimum local control.

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