Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma

Abstract

Background

To estimate the prognostic value of inflammatory markers in patients with laryngeal squamous cell carcinoma (LSCC).

Methods

A total of 361 resected LSCC patients were included. The preoperative and postoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), alkaline phosphatase (ALP) and l actate dehydrogenase (LDH) were assessed. The Kaplan-Meier survival analysis and Cox regression analysis were conducted on overall survival (OS) and progression-free survival (PFS).

Results

Both Kaplan-Meier analysis and univariate analysis demonstrated significant prognostic value of preoperative and postoperative NLR, PLR and MLR. However, only preoperative ALP was predictive of OS and PFS, and LDH failed to be predictor of OS and PFS. The multivariate analysis showed that preoperative NLR (OS: HR = 1.64, 95%CI: 1.06–2.54, p = 0.026; PFS: HR = 1.52, 95%CI: 1.04–2.23, p = 0.029) and postoperative MLR (OS: HR = 2.02, 95%CI: 1.29–3.14, p = 0.002; PFS: HR = 1.57, 95%CI: 1.05–2.34, p = 0.026) were independently related with survival.

Conclusions

The elevated preoperative NLR, PLR, MLR and ALP were significantly associated with worse survival and cancer progression. The preoperative NLR and postoperative MLR might be independent prognostic markers of OS and PFS in LSCC patients undergoing surgical resection.

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