Dimethyl Sulfoxide Prevents Radiation-induced Oral Mucositis through Facilitating DNA Double-strand Break Repair in Epithelial Stem Cell

We show that dimethyl sulfoxide (DMSO) exhibits marked protective activity against radiation-induced oral mucositis in mice without tumor protection, and the efficacy of DMSO is superior to that of rhKGF and amifostine. Administration of DMSO significantly prevents the loss of proliferative lingual epithelial stem and progenitor cells upon irradiation by facilitating DNA double-strand breaks repair. High efficacy and low toxicity of DMSO suggest possible therapeutic application.

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