Reply

We would like to respond to Dr Koumbourlis' letter. We took the approach in this analysis to focus on substantive, clinically meaningful change in respiratory status as our outcome measure. Physiologic changes of lung compliance could be measured in infants born premature exposed to diuretics in modern neonatal intensive care units; however, we feel that weaning off of positive pressure ventilation is important to families and staff more than short-term potential changes in peak inspiratory pressure and fraction of inspired oxygen.

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