Intra-treatment response assessment with 18F-FDG PET: Correlation of semi-quantitative PET features with pathologic response of esophageal cancer to neoadjuvant chemoradiotherapy

We extracted semi-quantitative PET features from 18F-FDG PET scans performed before and during neoadjuvant chemoradiotherapy for esophageal cancer and compared their accuracy in predicting histopathologic response. Volumetric PET features including metabolic tumor volume and total lesion glycolysis from the intra-treatment PET were the most accurate predictors of histopathologic response.

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