Therapeutic effects of human umbilical cord–derived mesenchymal stem cells on canine radiation-induced lung injury

Radiation-induced lung injury is a common complication following radiotherapy for thoracic tumours. Our studies show that canine radiation-induced lung injury could be observed at 180 days after X-ray radiation at 15 Gy, and intratracheal mesenchymal stem cell (MSC) transplantation can reduce oxidative stress, inflammatory reactions, and TGF-β/Smad2/3 pathway activation, thereby reducing lung injury. This finding provides a basis for the application of MSCs in clinical transplantation therapies for radiation-induced lung injury.

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