Temporal Small Arterial Inflammation is Common in Patients with Giant Cell Arteritis

Giant cell arteritis (GCA) primarily involves medium-to-large arteries. Small vessel inflammation is a recognized phenomenon occurring in association with GCA. However, its significance is poorly elucidated. Histologic sections and medical records of105 temporal artery specimens were retrospectively reviewed between 2008 and 2017 to examine associated clinical manifestations and laboratory data including ANA and p-ANCA titers. Immunohistochemical staining for CD4 and CD8 was performed in select cases to assess the nature of the inflammatory response.

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