In Regard to Chi et al

To the Editor: Chi et al (1) are to be commended for conducting the first randomized trial on the use of hyperthermia (HT) with radiation therapy (RT) versus RT alone for painful bone metastases (1). The study was terminated at the first interim analysis after accrual of 57 of a planned 152 eligible patients, owing to perceived superiority of the HT arm and slow recruitment. They reported complete pain relief (CR) rates within 3 months of treatment as 58.6% in the HT + RT group versus 32.1% in the RT-alone group (P = .045).

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