Correlation of Functional Lung Heterogeneity and Dosimetry to Radiation Pneumonitis using Perfusion SPECT/CT and FDG PET/CT Imaging

We apply our previously published framework for extracting dose-volume and dose-function parameters from SPECT/CT perfusion scans to both SPECT/CT and FDG PET/CT scans in an expanded cohort. We offer three perfusion parameters and one FDG PET parameter as candidate predictors of pneumonitis (to be validated in our ongoing functional lung avoidance interventional trial) and an analysis of inter-parameter cross-correlation that we hope will stimulate new discussions on determining optimal anatomic/functional parameter combinations for treatment planning.

https://ift.tt/2syrwZQ