An Automated Multiparametric MRI Quantitative Imaging Prostate Habitat Risk Scoring System for Defining External Beam Radiotherapy Boost Volumes

Prostate multiparamateric MRI has a high sensitivity and specificity for identifying tumor regions in the prostate; but, there is subjectivity in defining high risk 3D volumes that could be boosted, as opposed to entire prostate dose escalation. Registering to prostatectomy Gleason score, a habitat risk score based on pixel by pixel quantitative diffusion and perfusion was developed and then applied to guiding radiotherapy boost volumes in the background of a randomized Phase II clinical trial.

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