Criteria to Identify a Potential Deceased Organ Donor: A Systematic Review

Objectives: To systematically review the global published literature defining a potential deceased organ donor and identifying clinical triggers for deceased organ donation identification and referral. Data Sources: Medline and Embase databases from January 2006 to September 2017. Study Selection: All published studies containing a definition of a potential deceased organ donor and/or clinical triggers for referring a potential deceased organ donor were eligible for inclusion. Dual, independent screening was conducted of 3,857 citations. Data Extraction: Data extraction was completed by one team member and verified by a second team member. Thematic content analysis was used to identify clinical criteria for potential deceased organ donation identification from the published definitions and clinical triggers. Data Synthesis: One hundred twenty-four articles were included in the review. Criteria fell into four categories: Neurological, Medical Decision, Cardiorespiratory, and Administrative. Distinct and globally consistent sets of clinical criteria by type of deceased organ donation (neurologic death determination, controlled donation after circulatory determination of death, and uncontrolled donation after circulatory determination of death) are reported. Conclusions: Use of the clinical criteria sets reported will reduce ambiguity associated with the deceased organ donor identification and the subsequent referral process, potentially reducing the number of missed donors and saving lives globally through increased transplantation. This work was performed at The Ottawa Hospital Research Institute in Ottawa, ON, Canada. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (https://ift.tt/29S62lw). This study is part of the Canadian National Transplant Research Program and is supported, in part, by the Canadian Institutes of Health Research (Grant Number Transplantation Research - Full Application 127880). Drs. Squires', Coughlin's, Linklater's, Grimshaw's, and Knoll's institutions received funding from the Canadian Institutes of Health Research. Dr. Grimshaw received funding from Abbott Diagnostics Canada, Campbell Collaboration, Biomed Central, Canadian Patient Safety Institute, and National Health Service Education in Scotland. Dr. Shemie disclosed being the Medical Advisor, Deceased Donation for Canadian Blood Services. Dr. Dhanani disclosed being the research lead for Trillium Gift of Life Network. The remaining authors have disclosed that they do not have any potential conflicts of interest. For information regarding this article, E-mail: janet.squires@uottawa.ca Copyright © by 2018 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

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