Co-location of the polymyxin resistance gene mcr-1 and variant of mcr-3 on a plasmid in Escherichia coli from chicken farm [PublishAheadOfPrint]

A colistin-resistant Escherichia coli from commercial poultry farm in China carried two colistin-resistance genes mcr-1 and variant of mcr-3 in an IncP plasmid. The variant of mcr-3 gene, named mcr-3.11, encoded two amino acid substitutions compared with the mcr-3. A novel genetic structure, ISKpn40-mcr-3-dgkA- ISKpn40, might be the key element mediating translocation of mcr-3 through the formation of circular form. The mcr-1 and mcr-3 genes co-located on a plasmid might pose huge threat to public health.

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