Human hypothalamic neurons (HTNs) implicated in obesity have a limited availability. This study describes a reliable method for generating functional hormone-responsive HTNs from multiple normal and obese patient reprogrammed hiPSCs. Obese-patient-induced HTNs retained transcriptome profiles and functional phenotypes of high BMI, exhibiting aberrant obesity-related metabolic and respiratory pathways.
https://ift.tt/2HcxZDP
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
▼
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
-
▼
Απριλίου
(5349)
-
▼
Απρ 19
(225)
- Structure-Based Design: Synthesis, X-ray Crystallo...
- Pyramidatine (Z88) Sensitizes Vincristine-Resistan...
- Stereocomplexation Assisted Assembly of Poly(γ-glu...
- Global Research Highlights
- Table of Contents
- Adolescent Female With Right Ear Redness
- Editors
- Putting the Guidelines Ahead of the Evidence for t...
- Classified
- Young Woman With Postpartum Chest and Abdominal Pain
- Classified 2018 Advertising Rates & Information
- Clinical Policy: Critical Issues in the Evaluation...
- Calendar
- ACEP Accrediting Geriatric Emergency Departments
- American Board of Emergency Medicine Report on Res...
- Infant With Episodes of Bilious Vomiting
- Information for Readers
- EMRA EKG Guide
- What's Coming in Annals ● June 2018
- (Mis)understanding the Analysis of Apneic Oxygenat...
- In reply:
- In reply:
- Anti‐epidermal growth factor receptor therapy conc...
- Association of activities of daily living with the...
- Radio-pharmaceuticals for cancer treatment – are t...
- Functional immune characterization of HIV-associat...
- It’s time to rethink weight loss in cancer
- Letter to the editor on “Body mass index and 20-sp...
- Representation of Obese Participants in Obesity-Re...
- “ARTE and Craft of Bevacizumab in Elderly Patients...
- Tailoring treatment of salivary duct carcinoma (SD...
- Primary Tumor Sidedness and Benefit from FOLFOXIRI...
- Effects of Ascorbic Acid on Tax, NF-κB and MMP-9 i...
- Targeting Cell Necroptosis and Apoptosis Induced b...
- Mohs Micrographic Surgery Volume and Payment Patte...
- Characterization of PD-L1 and PD-1 Expression and ...
- The Impact of Epidemiological Factors and Treatmen...
- Optical trocar access for initial trocar placement...
- Belatacept and auto-immune adverse events
- More Than Just Wait Time? Regional Differences in ...
- Antigen Presentation Keeps Trending in Immunothera...
- Combined BRAF and HSP90 inhibition in patients wit...
- Tamoxifen Resistance Trumped and Oral Selective Es...
- Blockade of myeloid-derived suppressor cell expans...
- Universal influenza virus vaccines and therapeutic...
- Mapping of Leaf Rust Resistance Genes and Molecula...
- Phylogenetic and Phylogenomic Definition of Rhizop...
- Prescribing of Gluten-Free Foods Declining in England
- Opioids Tied to Adverse Outcomes in Hemodialysis P...
- First Opioid Lawsuit Targeting Pharmacy Benefit Ma...
- Most Smokers With Head and Neck Cancer Have Tried ...
- Adults Using Benzodiazepines More Likely to Receiv...
- NxtGen Botanicals Maeng Da Kratom by NGB Corp.: Re...
- NxtGen Botanicals Maeng Da Kratom by NGB Corp.: Re...
- Metastatic hepatocellular carcinoma masquerading a...
- Liquid‐based cytology in the diagnosis of Langerha...
- Cytodiagnosis of inflammatory myofibroblastic tumo...
- Evaluation of photoshop based image analysis in cy...
- Certain Kratom-Containing Powder Products by Viabl...
- Certain Kratom-Containing Powder Products by Viabl...
- Coming to the rescue of first responders
- An Ultra-clean Multilayer Apparatus for Collecting...
- Combining Microfluidics and Microrheology to Deter...
- Small Link for Cannabis Use, Reduced Cognitive Fun...
- Artificial Pancreas Treatment Efficacious for Type...
- Less Pain Post TKA With Addition of Peripheral Ner...
- Gene Therapy Found to Be Promising for β-Thalassemia
- Number of Cigarettes Smoked Daily Tied to Stroke Risk
- Hearing Aids May Mitigate Cognitive Decline, Memor...
- AAN: Erenumab Shows Promise for Hard-to-Treat Migr...
- Delayed Coronary Obstruction Rare After TAVR
- AAN: New Drug May Help Infants With Spinal Muscula...
- Time-Related Deployment Factors Predict Suicide At...
- Systematic review of the mesopancreas: concept and...
- Licorice-induced apparent mineralocorticoid excess...
- Localised perforation of locally advanced transver...
- Laparoscopic management of an internal hernia in a...
- Unexpected case of pneumomediastinum and subcutane...
- Massive haemoptysis secondary to mycotic pulmonary...
- Recognition of supraduodenal artery from hepatic a...
- Intestinal granulomatous disease: what is the firs...
- Cutaneous lymphangitis carcinomatosa made cervicof...
- Liver chemistry abnormalities and leg oedema in rh...
- Gas in the right hemiscrotum? Amyands hernia in a ...
- Spontaneous rupture of seminoma in undescended tes...
- Bilateral tension pneumothorax after acupuncture
- Retreatment with pembrolizumab in advanced non-sma...
- Incidence, pattern and prognosis of brain metastas...
- Dietary patterns, BCMO1 polymorphisms, and primary...
- AB0 blood groups and rhesus factor expression as p...
- Optimization of training periods for the estimatio...
- Prognostic factors of radiation dermatitis followi...
- Identification of Skeletal Muscle Satellite Cells ...
- Computational Analysis of the Caenorhabditis elega...
- Colorectal dysplasia and adenocarcinoma in patient...
- Clinical outcomes of ultrashort sloping shoulder i...
- A long‐term prospective cohort study on immediatel...
- Human Adult Neurogenesis: Evidence and Remaining Q...
- The Dystrophin Glycoprotein Complex Regulates the ...
- Super-Obese Patient-Derived iPSC Hypothalamic Neur...
-
▼
Απρ 19
(225)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 19 Απριλίου 2018
Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.