Radiation induced Secondary Tumors for Pediatric Central Nervous System Tumors Experiences of A Single Institute in Taiwan (1975-2013)

We analyzed the development of secondary tumors in 27 of 681 cases who received radiotherapy for pediatric brain tumors. The mean age was 8.8 years-old, the median radiation dose was 52.5 Gy, and the mean latency period was 14.6 years. Twenty-nine secondary tumors developed in 27 patients, corresponding to a 25-year cumulative incidence of 3.96%. Age below 7 years at irradiation, receipt of two-dimensional irradiation, and cranio-spinal irradiation increased the risk for a secondary tumor.

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