In Regard to Yoon et al

To the Editor: We read with interest this study by Yoon et al (1), who suggested harnessing the ultraviolet (UV) light (Cherenkov radiation) produced during megavoltage radiation therapy to photoactivate psolaren and cause DNA damage to irradiated cells. To test this approach, they generated light by applying megavoltage radiation to a solid-water slab, over which they had placed cancer cell cultures containing various concentrations of psolaren. They then measured cell viability, immunogenicity, and reproductive integrity and found that light generated in the slab, presumably through the Cherenkov effect, is sufficiently strong to photoactivate psolaren and cause detectable biological changes.

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