Failed Randomized Clinical Trials in Radiation Oncology: What Can We Learn?

Clinical trial failure is common and can have negative repercussions including wasted time and resources. Through a review of ClinicalTrials.gov for RCTs involving radiotherapy, we found 3 key findings: 1) the rates of failure for radiotherapy trials have been increasing over time, 2) trials with a surgical comparator were likely to fail, and 3) trials with behavioral comparators were more likely to succeed.

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