Definitive Radiation Therapy and Survival in Clinically Node-Positive Prostate Cancer

The survival benefit of combined radiation therapy and androgen deprivation therapy compared to androgen deprivation therapy alone for clinically lymph node-positive prostate cancer remains controversial. We identified clinically node-positive, non-metastatic prostate cancer patients from the Veterans Affairs system and compared mortality outcomes between treatment groups. We found that definitive treatment with radiation therapy improved prostate cancer-specific mortality and all-cause mortality, though only among patients with lower baseline prostate specific antigen.

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