Cost-effectiveness analysis of IMRT versus proton therapy for oropharyngeal squamous cell carcinoma

This study aimed to determine the cost-effectiveness of IMPT versus IMRT in node-positive oropharynx cancer. We found that IMRT was the cost-effective modality over a wide range of assumptions, many of which were biased in favor of proton therapy. However, IMPT has the potential to be cost-effective for younger patients with a favorable prognosis if its actual quality-of-life benefits are at the extreme ends of superiority over IMRT.

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