Multidrug Resistance: In Situ shRNA Synthesis on DNA–Polylactide Nanoparticles to Treat Multidrug Resistant Breast Cancer (Adv. Mater. 10/2018)

In situ rolling circle transcription (RCT) is applied by Qianqian Ni and co-workers to develop a "core–shell" microstructure. As described by Guizhi Zhu, Longjiang Zhang, Xiaoyuan Chen, and co-workers in article number 1705737, poly(short hairpin RNA) (shRNA) is synthesized on amphiphilic DNA–polylactide (PLA) nanoparticles for co-delivery of therapeutic shRNA and hydrophobic chemotherapeutics. Furthermore, polypeptide copolymer is used to shrink the microstructures into multifunctional nanoparticles.

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