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Identification of Fungal T Cell Epitopes by Mass Spectrometry-Based Proteomics.
Methods Mol Biol. 2017;1625:65-74
Authors: Roschitzki B, LeibundGut-Landmann S
Abstract
CD4+ T cells play a key role in host defense against many fungal infections. T cells are also implicated in vaccine immunity to fungi. To date, only a small number of fungal antigens have been identified. Knowing the antigenic determinants of fungi-specific T cells greatly facilitates the detection, enumeration and characterizes the antifungal T cells and it constitutes an important step toward the design and development of vaccination strategies. This chapter describes a method of MHC-II ligand elution and mass spectrometric analysis to identify naturally processed and presented fungal peptide epitopes.
PMID: 28584983 [PubMed - indexed for MEDLINE]
https://ift.tt/2pKC6MH
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