Extreme delta - with or without brushes: a potential surrogate marker of disease activity in anti-NMDA-receptor encephalitis

NMDARE is a treatable antibody-mediated neurological syndrome resulting in neuropsychiatric disturbances and seizures, which may evolve to severe encephalopathy, autonomic disturbance and orofacial dyskinesias (Dalmau et al. 2011). Clinical seizures are seen in 80% of cases (Dalmau et al. 2011) and EEG abnormalities in 90% (Titulaer et al. 2013), of which the potentially specific EEG pattern of "extreme delta brush" may carry worse prognosis (Schmitt et al. 2012) and may be associated with electrographic seizures (Veciana et al.

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