Acetaminophen in the Neonatal Intensive Care Unit: Shotgun Approach or Silver Bullet

The availability of intravenous acetaminophen (acetyl-para-aminophenol [APAP]) has resulted in an increase in the use of this drug in neonatal intensive care units for various indications. In term neonates undergoing major noncardiac surgery, it was shown that the use of intravenous APAP significantly decreased the amount of morphine needed to treat their pain.1 This potentially results in not only fewer opioid-related side effects, but also a much smaller number of neonates developing neonatal abstinence syndrome.

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