Primordial Odontogenic Tumour: Report of Two Cases

Abstract

Primordial odontogenic tumour (POT) is a rare mixed odontogenic neoplasm that is composed of primitive ecto-mesenchyme resembling dental papilla, surfaced by odontogenic epithelium resembling inner enamel epithelium, without hard tissue formation. Most reported cases have presented in the posterior mandible as a well-demarcated radiolucency associated with an unerupted tooth in the first two decades of life.

Aim

To describe the clinico-pathological features of two more cases of POT.

Methods and Results

Each presented as an asymptomatic well-delineated radiolucency in the mandible in a 15-year-old female and an 18-year-old male respectively. Both tumours were composed of a proliferation of plump spindle and stellate cells in delicately collagenous and myxoid stroma, surfaced by columnar-squamous epithelial cells with reverse nuclear polarization at the tumour periphery. In one case, the formation of abortive tooth germ-like structures was noted. This has not been reported before and supports the hypothesis of the primordial nature of this tumour. Both patients showed no recurrence at 3- and 20- month follow-up respectively.

Conclusion

This report describes two additional cases of POT, for a total of eleven cases reported in the English literature.

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