Plasma levels of rifampicin correlate with the TB drug activity (TDA) assay [PublishAheadOfPrint]

The plasma tuberculosis drug activity (TDA) assay may be an alternative tool for therapeutic drug monitoring in resource limited settings. In tuberculosis (TB) patients (n=30), TDA and plasma levels of first-line drugs were analysed two hours post dose, two weeks after treatment initiation. Patients with plasma levels of rifampicin below 8 mg/L had significantly lower median TDA (1.40 vs 1.68, p=0.0013). TDA may be used to identify TB patients with suboptimal rifampicin levels during TB treatment.

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