Correlation Between Tumor Metabolism and Semiquantitative Perfusion MRI Metrics in Non-small Cell Lung Cancer

Balance between vascularity and glucose metabolism in tumor could prove to be an important indicator of its biological status and resistance to treatment. This study evaluates the use of semiquantitative dynamic contrast-enhanced MRI parameters for predicting the 18F-FDG-PET maximum standardized uptake value in non-small cell lung cancer (NSCLC). It was found that intratumoral heterogeneity in wash-in contrast kinetics is associated with tumor metabolism. Investigating vascular-metabolic relationship will help in guiding personalized targeted therapy in NSCLC.

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