Challenges in Interpreting Multivariable Mendelian Randomization: Might “Good Cholesterol” Be Good After All?

Understanding the causal basis of disease is important so that we approach disease prevention and treatment using a valid etiologic framework. Blood lipids play an important role in the shuttling of nutrients (in the form of triglycerides and fatty acids) and cholesterol from the diet to the peripheral tissues. Certain types of blood lipids (eg, low-density lipoprotein cholesterol [LDL-C] and probably triglycerides [TG]) are atherogenic and lead to higher risks for coronary heart disease (CHD).1-6 The role of high-density lipoprotein cholesterol (HDL-C) to date has been more elusive.

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