Nectin-4 promotes gastric cancer progression via the PI3K/AKT signaling pathway

Nectin-4, a member of the Nectin family that includes four Ca+-independent immunoglobulin-like cell adhesion molecules, plays a carcinogenic role in multiple cancers. However, Nectin-4 expression and its biological role in gastric cancer (GC) remain largely unknown. In this study, quantitative real-time polymerase chain reaction (qRT-PCR), Western blotting, and immunohistochemistry (IHC) were used to evaluate the expression patterns of Nectin-4 in GC specimens and cell lines. We observed that high expression of Nectin-4 in GC patients was associated with TNM stage and lymph node metastasis status, and poor prognosis.

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