Tumor Cell Dynamics: Microenvironmental Stiffness of 3D Polymeric Structures to Study Invasive Rates of Cancer Cells (Adv. Healthcare Mater. 22/2017)

Three-dimensional cage-like microscaffolds with tailored Young's modulus are used to induce different invasive behaviours of cancer cells according to structural stiffness by Enrico Domenico Lemma, Ferruccio Pisanello, and co-workers in article number 1700888. Tumor cells invasion is boosted by softer architectures and by the presence of stiffness "weak spots" within overall rigid scaffolds, enabling more detailed analysis on mechanical interactions between tumor cells and the extracellular matrix.

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