High interlaboratory and interobserver agreement of somatostatin receptor immunohistochemical determination and correlation with response to somatostatin analogs

Monoclonal antibodies to somatostatin receptors 2A (SSTR2A, UMB-1) and 5 (SSTR5, UMB-4) were reported to be highly reliable for immunohistochemical detection of these receptors in neuroendocrine neoplasms. However, the standardization of either the immunohistochemical procedure and the methods of evaluation have yet to be established. Fifty-two tissues from 38 patients with neuroendocrine neoplasm were retrieved from two Institutions, in Italy and in Japan. The tissues were immunostained using three staining methodologies, one automated and two manual protocols from the Italian and Japanese Institutions.

http://ift.tt/2k08niZ