Influence of atrial contraction dynamics on cardiac function

Summary

In recent years, there has been a move from mono- or biventricular models of the heart, to more complex models that incorporate the electromechanical function in all four chambers. However, the biophysical foundation is still under-developed, with most work in atrial cellular models having focused on electrophysiological properties. Here we present a biophysical model of human atrial contraction at body temperature, and use it to study the effects of atrial contraction on whole organ function, and a study of the effects of remodelling due to atrial fibrillation on atrial and ventricular function. This article is protected by copyright. All rights reserved.

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