P 24 Electrophysiological connectivity during oscillatory cycles of alpha activity and the BOLD-signal correlate in major depression

Major depressive disorder (MDD) belongs to the leading causes of disability worldwide. From an electrophysiological point of view, EEG-alpha activity and alpha phase synchronization seem to be possible biomarkers with diagnostic and prognostic value. In parallel, functional magnetic resonance imaging (fMRI) studies suggest altered blood oxygen-level dependent (BOLD) signals in e.g. frontal and prefrontal brain areas (Lemogne et al., 2012). However, the association between electrophysiological alterations and differences of fMRI activity in MDD remains vague.

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