High-Dose Daptomycin and Mortality: The Case Is Not Yet Closed

To the Editor—In the 1 March 2017 issue of Clinical Infectious Diseases, Britt et al [1] reported on a cohort study of hospitalized Veterans Affairs (VA) patients treated with standard-, medium-, or high-dose daptomycin (6, 8, or ≥10 mg/kg total body weight, respectively) for vancomycin-resistant Enterococcus bloodstream infection. Although the authors conclude that high-dose daptomycin was associated with improved survival and microbiologic clearance in patients with such infection, we do not believe their data can be interpreted without additional information beyond what was presented in the article.

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