Novel NMR Techniques to Study Structural and Dynamical Properties of DNA Quadruplexes

Since the right-handed double helical conformation was first described by Watson and Crick (1), we have realized that DNA is highly polymorphic as evidenced by left-handed DNA (2), parallel-stranded DNA (3), DNA quadruplexes (4), and DNA i-motifs (5), to name a few. The conformation a particular segment of DNA assumes, as well as its thermodynamic stability and ligand binding properties, depend highly upon its sequence context and also on environmental conditions (e.g., temperature, cations present, pH, and so on).

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