Effects of seeding adipose-derived stem cells on electrospun nanocomposite used as chest wall graft in a murine model

Publication date: Available online 4 August 2017
Source:Injury
Author(s): Johanna Buschmann, Eleni Balli, Samuel C. Hess, Wendelin J. Stark, Paolo Cinelli, Sonja Märsmann, Manfred Welti, Walter Weder, Wolfgang Jungraithmayr
ObjectivesMalignant neoplasms infiltrating the chest wall often requires resection of the thoracic wall. To replace the defect, Gore-Tex^® is usually employed as the gold standard material, however, Gore-Tex^® is inert and not degradable. Novel materials are nowadays available which allow a full bio-integration due to their non-toxic degradability. Additionally, stem cell seeding has the capacity to reduce inflammatory response towards such grafts, thus integrating it better into the host organism.



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