Ali Khademhosseini and co-workers describe an engineered 3D fibrotic heart tissue, which is created by fabricating physiologically relevant cardiac tissues with native-like mechanical properties in article number 1601434. Upon exogenous stimulation with profibrotic transforming growth factor beta-1, these tissues reveal fibrogenic changes, such as collagen production, myofibroblast activation, and electrophysiological disturbances.
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