Spinal Canal Involvement in Neuroblastoma

Between 5% and 15% of children with neuroblastoma have spinal canal involvement (SCI) owing to tumor extension through the intervertebral foramina into the spinal canal. Patients with SCI are frequently less than 2 years of age, have biologically favorable disease, and usually experience excellent survival. Up to 65% of patients with SCI have symptoms and signs, including back pain, kyphoscoliosis, and neurologic signs (eg, paraparesis and/or paralysis, loss of motor skills, weakness, change in gait, and bladder or bowel dysfunction).

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