MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

When phosphorylated by RIPK3, MLKL triggers necroptotic death. Yoon et al. show that MLKL also contributes to endosomal trafficking and generation of extracellular vesicles. This function is independent of RIPK3 but can be enhanced by it, yielding phospho-MLKL release within the vesicles, thereby apparently withholding death mediation by MLKL.

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