Implementing Radiation Dose-Volume Liver Response in Biomechanical Deformable Image Registration

Deformable image registration (DIR) of the liver after radiotherapy is challenging due to the complex radiation dose-dependent volume response of normal hepatic tissue. A modified biomechanical modeling method for hepatic tissue including independent dose-driven deformation forces was developed and implemented on a series of patients, then compared with a previously developed biomechanical DIR algorithm. This proposed DIR technique resulted in improved target registration and deformed segment volume accuracy.

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