Reply

The comments of Finsterer and Zarrouk-Mahjoub expand the discussion of premature ovarian failure (POF) in patients with French Canadian Leigh Syndrome (FCLS). Our publication focused on POF in FCLS, an important and highly treatable aspect of this mitochondrial disease. We did not attempt to review the broad area of the relationships between mitochondria and the ovary. As Finsterer and Zarrouk-Mahjoub state, ovarian failure can occur in other mitochondrial diseases. Luteinizing hormone and follicle-stimulating hormone (FSH) levels were appropriately increased in FCLS women, their thyroid-stimulating hormone and prolactin levels were normal, and it was, therefore, not indicated to further investigate pituitary function or anatomy.

http://ift.tt/2qYjM4j