A lower baseline CD4/CD8 T-cell ratio is independently associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects [PublishAheadOfPrint]

We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pre-treatment CD4 counts, we observed a lower pre-treatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pre-treatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with main immunological alterations observed in immunodiscordants, including increased Treg frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV-variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.

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