The key role of rubella virus glycoproteins in the formation of immune response, and perspectives on their use in the development of new recombinant vaccines

Publication date: 17 February 2016
Source:Vaccine, Volume 34, Issue 8
Author(s): Ekaterina K. Petrova, Anastasia A. Dmitrieva, Ekaterina A. Trifonova, Nikolai A. Nikitin, Olga V. Karpova
Rubella is a highly contagious viral disease which is mostly threatens to women of reproductive age. Existent live attenuated vaccines are effective enough, but have some drawbacks and are unusable for a certain group of people, including pregnant women and people with AIDS and other immunodeficiency. Thereby the development of alternative non-replicating, recombinant vaccines undoubtedly is needed. This review discusses the protein E1 and E2 role in formation of immune response and perspectives in development of new generation recombinant vaccines using them.



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