HPV‐related cervical diseases: Alteration of vaginal microbiotas and promising potential for diagnosis

alexandrossfakianakis shared this article with you from Inoreader HPV‐related cervical diseases: Alteration of vaginal microbiotas and promising potential for diagnosis via Journal of Medical Virology Abstract Vaginal microbiota is closely associated with women's health, however, the correlation between HPV-related cervical disease (HRCD) and vaginal microbiota is still obscure. In this study, patients with HRCD (n=98) and healthy controls (n=58) in Hangzhou were recruited, their vaginal microbiota were collected and analyzed. The composition of vaginal microbial community was explored, and a disease classification model was developed by random forest algorithm. The results suggested that the diversity of vaginal microbiota was significantly higher in HRCDs than that in healthy controls (p<0.05). Firmicutes is the dominant phylum in vaginal microbiota, and Lactobacillus was identified as the most altered genus between two groups (p<0.01). Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis suggested the difference in vaginal microbial community functions between two groups. Furthermore, we identified 10 biomarkers as the optim al marker sets for random forest model and found higher probability of disease values in HRCD group in discovery cohort (p<0.0001), with an area under receiver operating characteristic (ROC) curve (AUC) reaching 89.7% (95% CI: 78.3%-100%). We further validated the model in both validation and independent diagnosis cohorts, confirming its accuracy in the prediction of HRCD. In conclusion, this study revealed the community composition of vaginal microbiota in HRCDs and successfully constructed a diagnostic model for HRCD. This article is protected by copyright. All rights reserved. View on Web

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Therapeutıc effect of alendronate ın an experımental temporomandıbular joınt osteoarthrıtıs

alexandrossfakianakis shared this article with you from Inoreader Therapeutıc effect of alendronate ın an experımental temporomandıbular joınt osteoarthrıtıs via Journal of Oral Rehabilitation Abstract Background Temporomandibular joint osteoarthritis is a common degenerative joint disease. This disease negatively affects the daily life, speech and chewing functions of patients. Objective This study aimed to evaluate the effects of intraarticular injection of alendronate to osteoarthritis, which has a protective effect on bone and cartilage tissue and helps reduce inflammation in temporomandibular joint osteoarthritis. Methods A total of 24 Wistar Albino rats were used in the study. Rats were divided into 4 groups as study, saline, control, and sham. In both saline and control groups, monosodium iodoacetate was injected intraarticularly to induce osteoarthritis. Alendronate was administered intraarticularly to the study group weekly for 4 weeks. In the saline group, saline was administered by intraarticular injection. At the end of the 12th week, all groups were sacrificed. Mandibular condyle tissues were examined histopathologically. Results According to the results, osteoarthritic changes in the control group were higher than those in the study group (p<0.05). No significant reduction in osteoarthritic changes was observed in the saline group (p>0.05). Significant osteoarthritis findings were observed in all groups compared to the sham group (p<0.05). Conclusion Intraarticular injection of alendronate was found to have positive results on TMJ osteoarthritis. In addition, it was seen that alendronate has effects on reducing cartilage tissue degeneration and loss of matrix proteins. View on Web

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Hemostasis in endoscopic sinus and skull base surgery

alexandrossfakianakis shared this article with you from Inoreader Hemostasis in endoscopic sinus and skull base surgery via Current Opinion in Otolaryngology & Head and Neck Surgery - Published Ahead-of-Print Purpose of review Bleeding during endoscopic endonasal procedures can quickly obscure critical anatomic landmarks. This increases both the difficulty of the surgical procedure and the risk of complications faced by the patient. As the indications for surgical management of sinonasal pathology grow, it is important to review techniques to minimize bleeding and facilitate safe surgery. Recent Findings Evidence continues to accumulate for best practices in the surgical management of sinonasal disease. Recently, international guidelines have attempted to summarize this body of evidence, lending further support to several interventions which have been advocated as methods to decrease bleeding during endoscopic endonasal surgery. Additional studies have specifically investigated the safety of certain commonly employed techniques. The utility of preoperative corticosteroid therapy and the use of total intravenous anesthetic techniques in increasingly validated. Further evidence supports the safety of reverse Trendelenburg positioning for surgical management of inflammatory disease. Summary Recent wide scale systematic review of the literature regarding perioperative and intraoperative management of hemostasis has reinforced the utility of certain interventions, while others remain ambiguous. View on Web

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Καρκίνος του Στομάχου – Νεώτερα Δεδομένα

[PDF] Καρκίνος του στομάχου

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Αλέξανδρος Γ. Σφακιανάκης

Αναπαύσεως 5 Άγιος Νικόλαος Λασιθίου 72100

2841026182

Τομογραφία Εκπομπής Ποζιτρονίων (PET) και υβριδικά συστήματα PET-ΜRI

[PDF] Τομογραφία εκπομπής ποζιτρονίων (PET) και υβριδικά συστήματα PET-MRI

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Αλέξανδρος Γ. Σφακιανάκης

Αναπαύσεως 5 Άγιος Νικόλαος Λασιθίου 72100

2841026182

00306932607174

Early warning signals for Omicron outbreaks

alexandrossfakianakis shared this article with you from Inoreader Early warning signals for Omicron outbreaks in China: a retrospective study via Journal of Medical Virology Abstract The Omicron variant has become the dominant COVID-19 variant worldwide due to its rapid and cryptic spread; therefore, successful early warning is of great importance to be able to control epidemics in their early phase, before developing into large outbreaks. COVID-19-related Baidu search index, which reflects human behavior to a certain degree, was used to retrospectively detect the warning signs for Omicron variant outbreaks in China in 2022. The characteristics and effects of warning signs were analyzed in detail. We detected the presence of early warning signs (both high and low thresholds) and found that these occurred 4–7 days earlier than traditional epidemiological surveillance and >20 days earlier than the implementation of the local "lockdown" policy. Compared with the "high threshold" warning, the early warning effect of the "low threshold" is also vital because it indicates a complacency about epidemic prevention and control. Ho wever, there is obvious heterogeneity in the optimal threshold for detecting early warning signs and their distribution in different cities. Multi-source and multi-point early warning systems should be established via combining internet-based big data in the future to conduct effective and early real-time warning. This would create precious time for the early control of COVID-19 outbreaks. This article is protected by copyright. All rights reserved. View on Web

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Salvage treatments for locally recurrent nasopharyngeal cancer: A systematic review and meta‐analysis

alexandrossfakianakis shared this article with you from Inoreader Salvage treatments for locally recurrent nasopharyngeal cancer: A systematic review and meta‐analysis via Head & Neck Abstract The present study aimed to evaluate the effectiveness and safety of various salvage treatments to treat locally recurrent nasopharyngeal carcinoma (IrNPC). A comprehensive search was conducted to gather relevant research publications on salvage treatment for IrNPC. Specifically, 2-, 3-, and 5-year overall survival were the primary outcome. A total of 89 studies with 101 cohorts were collected. Endoscopic nasopharyngectomy was found to be associated with a significantly improved 5-year OS compared with CRT (p = 0.027) and IMRT (p = 0.016). Moreover, based on recurrence T classification, the 2-, 3-, and 5-year OS were similar across different treatments. Endoscopic nasopharyngectomy was associated with a significant reduction in treatment-related complications (grade ≥ 3) compared with IMRT (p < 0.001) and open nasopharyngectomy (p = 0.028). Endoscopic nasopharyngectomy may provide comparable treatment outcomes t o re-irradiation, while offering a better safety profile for selective patients with resectable IrNPC. View on Web

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