Αρχειοθήκη ιστολογίου

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Τετάρτη 17 Ιουλίου 2019

Computer Assisted Tomography

Imaging of Usual and Unusual Complication of Rotator Cuff Repair
imageSeveral complications may be encountered after rotator cuff (RC) repair. A thorough knowledge of surgical interventions, normal postoperative findings, and postoperative complications is crucial to provide a timely diagnosis, improving the clinical outcome of patients. Postoperative complications may involve RC, implanted device, osteochondral tissue, surgical-site infection, peripheral nerves, soft tissues, and vascular structures. In this review, we discuss the usual and unusual complications detectable after RC repair.

An Ancillary Sign in the Diagnosis of Bankart and Bankart Variants in Patients With Glenohumeral Instability on Nonarthrographic Magnetic Resonance Imaging: Preglenoid Fat Thickness
imageObjective We investigated whether preglenoid fat thickness can be used as an ancillary sign for preliminary diagnosis of Bankart and its variants on nonarthrographic magnetic resonance imaging. Materials and Methods Sixty-eight anterior dislocation patients were included in this retrospective study. Forty-eight patients with Bankart and its variants, as detected by arthroscopy and magnetic resonance arthrography, were included in the study group. The study group was divided into osseous Bankart, labral Bankart, Perthes, and anterior labroligamentous periosteal sleeve avulsion subgroups. Twenty patients with no detected labral pathologies by arthroscopy and magnetic resonance arthrography were included in the control group. In these patients, preglenoid fat tissue thickness at the anteroinferior portion was measured at the level of the glenoid tubercle. Thickness of preglenoid fat tissue was compared between groups with different labral pathologies and those with normal labrum. Results The preglenoid fat tissue thickness was 2.65 ± 1.05 mm in the control group and 0.90 ± 0.59 mm in the study group (P < 0.0001). Patients with preglenoid fat tissue thinner than 1.6 mm showed a significantly increased likelihood of having Bankart and its variants in receiver operating characteristic analysis (sensitivity of 95.8% and specificity of 85%). There was no significant difference in preglenoid fat tissue thickness between the subgroups of the study group (osseous Bankart, labral Bankart, Perthes, and anterior labroligamentous periosteal sleeve avulsion). Conclusion Preglenoid fat tissue measurement can be used as an ancillary sign in the diagnosis of Bankart and Bankart variants in glenohumeral instability patients.

Comparison of Cone-Beam Computed Tomography and Multislice Computed Tomography in the Assessment of Extremity Fractures
imageObjectives The aims of this study were to evaluate the agreement between cone-beam computed tomography (CBCT) and multislice computed tomography for the characterization of extremity fractures and to compare image quality, radiation dose, and patient tolerance. Methods Thirty-six patients with suspected fracture affecting distal extremities or who required preoperative fracture assessment were enrolled prospectively. Each patient underwent CBCT and multislice computed tomography the same day. Both examinations were evaluated independently twice by 2 trained radiologists using the Müller AO classification for fracture characterization. Results Cohen κ coefficient for agreement between the imaging techniques was almost perfect for fracture characterization, κ = 0.94 [95% confidence interval, 0.91–0.98]. There was substantial to almost perfect agreement for secondary findings. Cone-beam computed tomography was well tolerated and significantly less irradiant and had better subjective image. Conclusions An excellent agreement between both imaging techniques was found. This confirms the ability of CBCT to assess fractures and its potential in the management of patients with distal limb trauma.

Dual-Energy Computed Tomography in Loosening of Revision Hip Prosthesis: A Comparison Between MARS and non-MARS Images
imagePurpose The aim of the study was to assess potential endoprosthesis loosening in patients after revision total hip arthroplasty, based on monochromatic dual-energy computed tomography (DECT) images obtained with and without metal artifact reduction software (MARS) and comparison with the clinical examination and hip function. Materials and Methods Twenty-five consecutive patients underwent DECT examinations. Two monochromatic data sets were generated: with MARS (75-keV MARS) and without MARS (140-keV non-MARS) and evaluated for signs of loosening, using a dedicated radiological score. The Harris Hip Score (HHS) was used to evaluate patients' hip function. Results The mean radiological score for loosening in the non-MARS group was 16.2, in the MARS group 17.0 and was significantly higher (P < 0.001). Radiological loosening evaluation in non-MARS images correlated with the HHS score (ρ = 0.43, P = 0.03), whereas there was no correlation between MARS images and HHS (ρ = 0.15, P = 0.47). New MARS-related artifacts, which hinder implant-bone interface evaluation, were found in 75-keV MARS images ("pseudo-loosening" in 33 of 34 prostheses, "ground-glass blurring" in 20 of 32). Conclusions High-energy monochromatic DECT images are superior to low-energy DECT MARS images in assessment of the potential loosening and correlate better with the clinical examination outcomes. For revision total hip arthroplasty evaluation, 2 data sets should be assessed inseparably because of extra artifacts in MARS images.

Value of the Cinematic Rendering From Volumetric Computed Tomography Data in Evaluating the Relationship Between Deep Soft Tissue Sarcomas of the Extremities and Adjacent Major Vessels: A Preliminary Study
imageObjective The aim of the study was to assess the value of cinematic rendering (CR) from volumetric computed tomography data in evaluating the relationship between deep soft tissue sarcomas (STSs) of the extremities and the adjacent major vessels. Methods Preoperative contrast-enhanced axial imaging (CEAI) in the arterial phase with three-dimensional volume rendering (VR) and CR of contrast-enhanced computed tomography were used to assess adjacent vascular invasion in 43 cases of deep STSs of the extremities. The imaging assessments were compared with surgical findings and interpreted as negative (no vascular invasion) or positive (vascular invasion was present). Intrareader and interreader agreement were assessed using Cohen κ statistics. The diagnostic performance of CEAI, VR, and CR was evaluated by receiver operating curve analysis and compared using the DeLong test. Results Thirty-four and nine cases were classified as negative and positive, respectively, in surgery. Intrareader agreement values for the CEAI, VR, and CR assessments were all excellent (0.984, 0.934, and 0.914, respectively), whereas the interreader agreement for CEAI assessments was greater than that for VR and CR (0.969 vs 0.804 and 0.761). Cinematic rendering showed lower accuracy (0.698), sensitivity (0.778), specificity (0.676), positive predictive values (0.389), and negative predictive values (0.920) for vascular invasion diagnosis than CEAI or VR; the accuracy, sensitivity, specificity, positive predictive values, and negative predictive values increased to 0.767, 0.889, 0.735, 0.471, and 0.962 for both CEAI and VR. The results were not statistically significant (all P > 0.05). Conclusions Cinematic rendering has the potential to be used to evaluate vascular invasion in cases of deep STSs of the extremities, but it should be used alongside the traditional methods such as CEAI.

Kinematic Analysis of the Distal Radioulnar Joint in Asymptomatic Wrists Using 4-Dimensional Computed Tomography–Motion Pattern and Interreader Reliability
imagePurpose The aim of this study was to determine the normal measurement values and interobserver performance of the distal radioulnar joint during wrist pronation-supination using 4-dimensional computed tomography (CT). Methods Four-dimensional CT examinations were performed on the asymptomatic contralateral wrists of 10 patients with unilateral chronic wrist pain. Measurements were conducted using the modified radioulnar (mRU) line and epicenter (Epi) methods. Volar subluxation of the ulnar head was demonstrated with negative values. Wilcoxon rank sum test was used to determine the measurement changes. Interobserver agreements were assessed using interclass correlation coefficients. Results In pronation, mRU line measurements (median, 0.09; interquartile range, 0–0.15) were significantly larger than in supination (median, −0.1; interquartile range, −0.18 to 0; P = 0.008).The Epi measurements were not significantly different in pronation (median, 0.03; interquartile range, 0.01–0.07) and supination (median, 0.06; interquartile range, 0.01–0.1; P = 0.799). There was an excellent inter-observer agreement between the two readers using mRU and Epi methods in pronation (0.982, 0.898), midpoint (0.994, 0.827) and supination (0.989, 0.972) positions, respectively. Conclusions Using 4-dimensional CT examination, distal radioulnar joint kinematics in asymptomatic wrists demonstrate excellent interobserver agreements with increased volar ulnar subluxation with supination as detected using mRU, but not the Epi method.

Computed Tomography Angiography and Magnetic Resonance Angiography of Congenital Anomalies of Pulmonary Veins
imageWe aimed to review computed tomography and magnetic resonance angiography of congenital anomalies of pulmonary veins. Total anomalous pulmonary venous return shows all pulmonary veins drain abnormally in another site rather than left atrium. Imaging can detect anomalous veins either supracardiac, infracardiac, or mixed. Partial anomalous pulmonary venous return shows some pulmonary vein have abnormal drainage that well delineated with computed tomography angiography. Scimitar syndrome is a type of partial anomalous pulmonary venous return where the pulmonary veins of the right lung drain infracardiac and is associated with right lung hypoplasia and dextrocardia. Pseudoscimitar show anomalous vein that takes a tortuous course and drains into the left atrium producing a false-positive scimitar sign. Cor triatriatum shows septum divide left atrium with proximal chamber receives blood flow from the pulmonary veins. Levoatriocardinal vein is an anomalous connection between the left atrium and anomalous vein from systemic venous system that is embryo logically derived from the cardinal veins. Computed tomography angiography can detect pulmonary vein stenosis, atresia, hypoplasia, and varix. Imaging is important for intimal diagnosis and detects the anomalous vessels and its connection, presence of stenosis, and associated other congenital cardiac anomalies. Also, it is a great role in assessment of patients after surgery.

Circulatory Stasis or Thrombus in Left Atrial Appendage, An Easy Diagnostic Solution
imageObjective The purpose of this study was to assess the diagnostic performance of prone position cardiac multidetector computed tomography (MDCT) in the detection of left atrial appendage (LAA) thrombi and to make differentiate between thrombus and circulatory stasis using transesophageal echocardiography (TEE) as the criterion-standard imaging modality. Methods From December 2014 to April 2016, 53 consecutive patients were admitted to the hospital because of circulatory stasis or/and thrombus. All patients underwent prone-position MDCT and TEE. Prone-position MDCT and TEE sensitivity, specificity, positive predictive value, and negative predictive value were calculated. Results For the MDCT scan in the prone position, the sensitivity, specificity, positive predictive value, and negative predictive value results were 100%, 100%, 100%, and 100%, respectively. Conclusions Multidetector computed tomography scanning in the prone position differentiates circulatory stasis and LAA thrombus, is clinically useful for detecting and ruling out LAA thrombus, and may be an alternative to TEE as a diagnostic tool.

Cardiovascular Magnetic Resonance Provides Evidence of Abnormal Myocardial Strain and Primary Cardiomyopathy in Marfan syndrome
imageObjective Marfan syndrome is an autosomal-dominant genetic disorder caused by mutations in the fibrillin-1 gene. The condition is a connective tissue disease that frequently involves the cardiovascular system. The existence of a primary cardiomyopathy in Marfan syndrome, however, is controversial. The aims of this study were to investigate the prevalence of left ventricular dysfunction with both transthoracic echocardiography and cardiovascular magnetic resonance (CMR) in a cohort of Marfan syndrome patients and to investigate patterns of myocardial strain across the cohort. Methods We used an institutional database to identify all patients with a firm diagnosis of Marfan syndrome based on Ghent criteria. Inclusion required left ventricular ejection fraction (LVEF) to have been measured by both CMR and transthoracic echocardiography within 12 months of each other. Normal LVEF was defined as a value of >55% when measured by CMR. Velocity vector imaging was used to measure left ventricular longitudinal strain patterns by application of feature tracking to cine magnetic resonance images. Results were compared with data from 20 age-matched control subjects. Results Sixty-nine Marfan syndrome patients met the inclusion criteria. The mean age was 35.4 ± 15.0 years, and 56.5% were male. The mean LVEF was 59.0% ± 7.0% by CMR and 59.1% ± 5.8% by echo. One-fifth of Marfan syndrome patients (15/69; 21.7%) had reduced function with LVEF ≤55% by CMR, but only 5 of these were identified by echo. Furthermore, echo identified 5 Marfan syndrome patients as having reduced LVEF in the presence of a normal LVEF by CMR. Some Marfan syndrome patients had abnormal longitudinal strain patterns even with LVEF within the reference range. Conclusions These data provide support for a primary cardiomyopathy in some Marfan syndrome patients. Cardiovascular magnetic resonance is more sensitive than echo for identifying cases with mild systolic dysfunction. Strain analysis may be more sensitive than simple LVEF assessment for identifying at-risk individuals.

Does the Tube Voltage Affect the Characterization of Coronary Plaques on 100- and 120-kVp Computed Tomography Scans
imageObjective The aim of this study was to compare the diagnostic performance of 100- and 120-kVp coronary computed tomography (CT) angiography (CCTA) scans for the identification of coronary plaque components. Methods We included 116 patients with coronary plaques who underwent CCTA and integrated backscatter intravascular ultrasound studies. On 100-kVp scans, we observed 24 fibrous and 24 fatty/fibrofatty plaques; on 120-kVp scans, we noted 27 fibrous and 41 fatty/fibrofatty plaques. We compared the fibrous and the fatty/fibrofatty plaques, the CT number of the coronary lumen, and the radiation dose on scans obtained at 100 and 120 kVp. We also compared the area under the receiver operating characteristic (ROC) curve of the coronary plaques on 100- and 120-kVp scans with their ROC curves on integrated backscatter intravascular ultrasound images. Results The mean CT numbers of fatty and fatty/fibrofatty plaques were 5.71 ± 36.5 and 76.6 ± 33.7 Hounsfield units (HU), respectively, on 100-kVp scans; on 120-kVp scans, they were 13.9 ± 29.4 and 54.5 ± 22.3 HU, respectively. The CT number of the coronary lumen was 323.1 ± 81.2 HU, and the radiation dose was 563.7 ± 81.2 mGy-cm on 100-kVp scans; these values were 279.3 ± 61.8 HU and 819.1 ± 115.1 mGy-cm on 120-kVp scans. The results of ROC curve analysis identified 30.5 HU as the optimal diagnostic cutoff value for 100-kVp scans (area under the curve = 0.93, 95% confidence interval = 0.87–0.99, sensitivity = 95.8%, specificity = 78.9%); for 120-kVp plaque images, the optimal cutoff was 37.4 HU (area under the curve = 0.87, 95% confidence interval = 0.79–0.96, sensitivity = 82.1%, specificity = 85.7%). Conclusions For the discrimination of coronary plaque components, the diagnostic performance of 100- and 120-kVp CCTA scans is comparable.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Bone & Joint Surgery

Publons: The Next Step in Reviewer Recognition
No abstract available

What's New in Orthopaedic Trauma
No abstract available

Use of Povidone-Iodine Irrigation Prior to Wound Closure in Primary Total Hip and Knee Arthroplasty: An Analysis of 11,738 Cases
imageBackground: Povidone-iodine (PI) irrigation is often used prior to wound closure in total joint arthroplasty, but there are limited reports evaluating its efficacy in decreasing joint infections. The goal of this study was to compare the rate of any reoperation for infection (both superficial and deep) in primary total hip arthroplasty (THA) and primary total knee arthroplasty (TKA) among patients who did and did not receive PI irrigation prior to wound closure. Methods: Using our institution's total joint registry, we identified 5,534 primary THA and 6,204 primary TKA procedures performed from 2013 to 2017. Cases were grouped on the basis of whether or not the wound was irrigated with 1 L of 0.25% PI prior to closure. PI irrigation was used in 1,322 (24%) of the THA cases and in 2,410 (39%) of the TKA cases. The rates of reoperation for infection at 3 months and 1 year were compared between the 2 groups. The same comparisons were then performed using propensity scores to account for differences in baseline characteristics. Results: The rate of reoperation for infection as assessed at 3 months following THA was similar between those who received dilute PI irrigation (0.9%) and who did not (0.7%) (p = 0.7). At 1 year, the rate of reoperation for infection was similar between those who received dilute PI irrigation (0.7%) and those who did not (0.9%) (p = 0.6). After using the propensity score, there was no difference between the groups in the risk of septic reoperations. For TKA, the rate of reoperation as assessed at 3 months was similar between those who received dilute PI irrigation (0.8%) and those who did not (0.3%) (p = 0.06). At 1 year, there was a greater rate of reoperations for infection among those who received dilute PI irrigation (1.2%) compared with those who did not (0.6%) (p = 0.03). However, there was no difference in the risk of septic reoperations between the groups after using the propensity score. Conclusions: Despite enthusiasm for and progressive adoption of the use of dilute PI irrigation at our institution, there was not a significant reduction in the risk of reoperation for infection as assessed at 3 months and 1 year following primary THA and TKA. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

Povidone-Iodine Wound Lavage to Prevent Infection After Revision Total Hip and Knee Arthroplasty: An Analysis of 2,884 Cases
imageBackground: Postoperative infection remains a major challenge in revision total hip arthroplasty (THA) and revision total knee arthroplasty (TKA). Wound irrigation with dilute povidone-iodine (PI) solution has emerged as a simple, inexpensive, and potentially successful means of reducing postoperative infections. The aim of this study was to assess its effectiveness in reducing infection following revision THA and TKA in, to our knowledge, the largest revision cohort to date. Methods: Using our institution's total joint registry, we identified 1,402 revision THAs and 1,482 revision TKAs performed during the study period (2013, when the PI irrigation protocol was first implemented, to 2017). The PI lavage protocol was employed in 27% of the revision THA cases and 34% of the revision TKA cases; in the remaining cases, the protocol was not used. Demographics, comorbid conditions, underlying surgical diagnoses, and whether the revision was for a septic or an aseptic etiology were compared between the groups (use or no use of PI irrigation). Any reoperation due to infection, as assessed at 3 and 12 months following revision arthroplasty, was compared between the groups and propensity scores were calculated to account for differences in baseline characteristics between the groups. Results: After adjusting for baseline differences between the groups using the propensity-score weighted models, we found no significant difference in the rate of reoperation for infection at 3 months (p = 0.58 for revision THA, and p = 0.06 for revision TKA) and at 12 months (p = 0.78 for revision THA, and p = 0.06 for revision TKA). Nonetheless, the hazard ratios from the propensity-score model trended higher for patients who received PI lavage: 1.6 and 1.3 for revision THA at 3 and 12 months, respectively, and 2.9 at both 3 and 12 months for revision TKA. Conclusions: PI wound lavage demonstrated no benefit in reducing any reoperation for infection following revision THA and TKA. Moreover, the trend toward higher rates for reoperation for infection among patients who received PI irrigation merit further consideration. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

Association of Race and Ethnicity with Total Hip Arthroplasty Outcomes in a Universally Insured Population
imageBackground: Prior studies have documented racial and ethnic disparities in total hip arthroplasty (THA) outcomes in the U.S. The purpose of this study was to assess whether racial/ethnic disparities in THA outcomes persist in a universally insured population of patients enrolled in an integrated health-care system. Methods: A U.S. health-care system total joint replacement registry was used to identify patients who underwent elective primary THA between 2001 and 2016. Data on patient demographics, surgical procedures, implant characteristics, and outcomes were obtained from the registry. The outcomes analyzed were lifetime revision (all-cause, aseptic, and septic) and 90-day postoperative events (infection, venous thromboembolism, emergency department [ED] visits, readmission, and mortality). Racial/ethnic differences in outcomes were analyzed with use of multiple regression with adjustment for socioeconomic status and other potential confounders. Results: Of 72,755 patients in the study, 79.1% were white, 8.2% were black, 8.5% were Hispanic, and 4.2% were Asian. Compared with white patients, lifetime all-cause revision was lower for black (adjusted hazard ratio [HR], 0.79; 95% confidence interval [CI], 0.66 to 0.94; p = 0.007), Hispanic (adjusted HR, 0.73; 95% CI, 0.61 to 0.87; p = 0.002), and Asian (adjusted HR, 0.49; 95% CI, 0.37 to 0.66; p < 0.001) patients. Ninety-day ED visits were more common among black (adjusted odds ratio [OR], 1.15; 95% CI, 1.05 to 1.25; p = 0.002) and Hispanic patients (adjusted OR, 1.18; 95% CI, 1.08 to 1.28; p < 0.001). For all other postoperative events, minority patients had similar or lower rates compared with white patients. Conclusions: In contrast to prior research, we found that minority patients enrolled in a managed health-care system had rates of lifetime reoperation and 90-day postoperative events that were generally similar to or lower than those of white patients, findings that may be related to the equal access and/or standardized protocols associated with treatment in the managed care system. However, black and Hispanic patients still had higher rates of 90-day ED visits. Further research is required to determine the reasons for this finding and to identify interventions that could reduce unnecessary ED visits. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

Regional or General Anesthesia in the Surgical Treatment of Distal Radial Fractures: A Randomized Clinical Trial
imageBackground: Most patients undergoing surgery for the treatment of a distal radial fracture are treated in a day-surgery setting and are given either general anesthesia (GA) or regional anesthesia (RA). The main purpose of this study was to investigate the impact of the anesthesia method on patients' postoperative opioid consumption during the first 3 days following surgery. Methods: This was a single-center randomized clinical trial. A total of 88 patients aged 18 to 74 years who were undergoing day surgery for the treatment of a displaced distal radial fracture with volar-plate fixation were randomized to GA (n = 44) or RA with a supraclavicular brachial plexus blockade (n = 44). The primary outcome was total opioid equivalent consumption (OEC) during the first 3 postoperative days (72 hours). Secondary outcomes included OEC during days 1, 2, and 3, visual analog scale (VAS) for pain scores, maximum pain, postoperative nausea and vomiting, perioperative time consumption (surgical, preoperative, and postoperative anesthesia care time), functional outcomes, and Patient-Rated Wrist Evaluation (PRWE) and EuroQol-5 Dimensions-3 Levels (EQ-5D-3L) scores up to 6 months. Results: The total median OEC during the first 3 postoperative days was 85 mg (range, 0 to 218 mg) in the GA group and 60 mg (range, 3 to 150 mg) in the RA group (p = 0.1). The groups differed significantly in OEC and VAS for pain scores during the first 24 hours after surgery; the median OEC was higher in the GA group before discharge (p < 0.001), while it was higher in the RA group after discharge (p < 0.001). Patients in the GA group reported more pain immediately after surgery (median score, 6; width of interquartile range [IQR], 7) and at 2 hours postoperatively (median score, 2; width of IQR, 3) compared with patients in the RA group (median score, 0; width of IQR, 0 at both time points) (p < 0.001). Maximum pain occurred at a median of 1 hour (range, 1 hour to 22 hours) after the end of surgery in the GA group compared with a median of 11 hours (range, 1 hour to 24 hours) in the RA group (p < 0.001). The total median perioperative time consumption was 244 minutes (range, 114 to 389 minutes) in the GA group compared with 146 minutes (range, 74 to 390 minutes) in the RA group (p < 0.001). There were no significant differences in functional outcomes or PRWE or EQ-5D-3L scores at 6 months. Conclusions: The anesthesia method (GA vs. RA) significantly influenced the early patterns of postoperative pain and opioid consumption after surgical treatment of a distal radial fracture, but neither total OEC over the first 3 postoperative days nor longer-term outcomes differed between the groups. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.

Step Activity After Surgical Treatment of Ankle Arthritis
imageBackground: Ambulatory activity is reduced in patients with ankle arthritis. In this study, we measured step activity over time in 2 treatment groups and secondarily compared step activity with results of patient-reported outcome measures (PROMs). Methods: Patients who were treated with either ankle arthrodesis or ankle arthroplasty wore a step activity monitor preoperatively and at 6, 12, 24, and 36 months postoperatively. Changes from preoperative baseline in total steps per day and per-day metrics of low, medium, and high-activity step counts were measured in both treatment groups. Step activity was compared with each subject's PROM scores as reported on the Musculoskeletal Function Assessment (MFA) and the Short Form-36 (SF-36) physical function and bodily pain subscales. Results: Of the 3 activity levels, combined group high-activity step counts showed the greatest increase (mean of 278 steps [95% confidence interval (CI), 150 to 407 steps], a 46% improvement from preoperatively). At 6 months, the mean high-activity step improvement for the arthroplasty group was 194 steps compared with a mean decline of 44 steps for the arthrodesis group (mean 238-step difference [95% CI, −60 to 536 steps]). By 36 months postoperatively, the greater improvement in high-activity steps for the arthroplasty versus the arthrodesis group was no longer present. There were no significant pairwise differences in improvement based on surgical treatment method at any individual follow-up time point. For a within-patient increase of 1,000 total steps, there was a mean change in the MFA, SF-36 physical function, and SF-36 bodily pain scores of −1.8 (95% CI, −2.4 to −1.2), 3.8 (95% CI, 2.8 to 4.8), and 2.8 (95% CI, 1.8 to 3.9), respectively (p < 0.0001 for all associations). There was no evidence that the association differed by study visit, or by study visit and surgical procedure interaction (p > 0.10). Conclusions: Surgical treatment of ankle arthritis significantly improves ambulatory activity, with greater change occurring at high activity levels. Improvement may occur more quickly following arthroplasty than arthrodesis, but at 3 years, we detected no significant difference between the 2 procedures. Step counts, while associated with PROMs, do not parallel them, and thus may be a useful supplementary measure, particularly in longitudinal studies. Level of Evidence: Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.

Cemented Versus Cementless Total Knee Arthroplasty of the Same Modern Design: A Prospective, Randomized Trial
imageBackground: Highly porous surfaces promoting biologic fixation have renewed interest in cementless total knee arthroplasty (TKA), but the potential for failed biologic fixation remains. The purpose of this study was to compare the clinical outcomes of cemented and cementless versions of the same TKA design at an average of 2 years postoperatively. Methods: This was an institutional review board-approved, prospective, randomized controlled trial of patients from 18 to 75 years of age who were undergoing a primary TKA. Patients with inflammatory arthritis, a body mass index (BMI) of >40 kg/m2, infection, a neuromuscular disorder, or grossly osteoporotic bone or bone defects were excluded. Patients were randomized to receive a cemented or cementless cruciate-retaining TKA of the same design. The cementless implant has highly porous fixation surfaces. Oxford Knee, Knee Society, and Forgotten Joint Scores were collected. Patients were asked to rate the knee with the TKA as a percentage of normal. Power analysis indicated that 130 patients were necessary to demonstrate a 5-point difference in the Oxford Knee Score at 90% power. Results: One hundred and forty-seven patients were enrolled, and 141 (96%) of them were analyzed at an average of 2 years postoperatively. There was no difference in age, sex, BMI, American Society of Anesthesiologists (ASA) score, or duration of follow-up (p = 0.1 to 0.9). There was also no difference in the change in the hemoglobin level from the preoperative measurement to postoperative day 1 between the 2 cohorts (mean and standard deviation, −2.6 ± 1.4 g/dL compared with −2.5 ± 0.9 g/dL, p = 0.5), but the total operative time was decreased in the cementless cohort (82.1 ± 16.6 compared with 93.7 ± 16.7 minutes, p = 0.001). There were no differences in any clinical outcome measure at 4 to 6 weeks, 1 year, or an average of 2 years postoperatively (p = 0.1 to 0.9) between the cemented and cementless cohorts. There was no radiographic evidence of component subsidence or loosening in either cohort. Conclusions: This study demonstrated that a recently introduced cementless TKA had results, both perioperatively and at an average of 2 years postoperatively, that were equivalent to those of its cemented predecessor, without any aseptic failures of either implant. Thus, this study justifies continued surveillance of this device to elucidate both its survivorship and if it can provide any long-term benefits. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.

Virtual Mechanical Testing Based on Low-Dose Computed Tomography Scans for Tibial Fracture: A Pilot Study of Prediction of Time to Union and Comparison with Subjective Outcomes Scoring
imageBackground: Quantitative outcomes assessment remains a persistent challenge in orthopaedic trauma. Although patient-reported outcome measures (PROMs) and radiographic assessments such as Radiographic Union Scale for Tibial Fractures (RUST) scores are frequently used, very little evidence has been presented to support their validity for measuring structural bone formation or biomechanical integrity. Methods: In this pilot study, a sequential cohort of patients with a tibial shaft fracture were prospectively recruited for observation following standard reamed intramedullary nailing in a level-I trauma center. Follow-up at 6, 12, 18, and 24 weeks included radiographs and completion of PROMs (EuroQol 5-Dimension [EQ-5D] and pain scores). Low-dose computed tomography (CT) scans were also performed at 12 weeks. Scans were reconstructed in 3 dimensions (3D) and subjected to virtual mechanical testing via the finite element method to assess torsional rigidity in the fractured limb relative to that in the intact bone. Results: Patients reported progressive longitudinal improvement in mobility, self-care, activity, and health over time, but the PROMs were not correlated with structural bone healing. RUST scoring showed moderate intrarater agreement (intraclass coefficient [ICC] = 0.727), but the scores at 12 weeks were not correlated with the time to union (R2 = 0.104, p = 0.193) and were only moderately correlated with callus structural integrity (R2 = 0.347, p = 0.010). In contrast, patient-specific virtual torsional rigidity (VTR) was significantly correlated with the time to union (R2 = 0.383, p = 0.005) and clearly differentiated 1 case of delayed union (VTR = 10%, union at 36 weeks) from the cases in the normally healing cohort (VTR > 60%; median union time, 19 weeks) on the basis of CT data alone. Conclusions: PROMs provide insight into the natural history of the patient experience after tibial fracture but have limited utility as a measure of structural bone healing. RUST scoring, although reproducible, may not reliably predict time to union. In contrast, virtual mechanical testing with low-dose CT scans provides a quantitative and objective structural callus assessment that reliably predicts time to union and may enable early diagnosis of compromised healing. Level of Evidence: Therapeutic Level IV. Please see Instructions for Authors for a complete description of levels of evidence.

The Effect of Coronal Alignment on Tibial Component Migration Following Total Knee Arthroplasty: A Cohort Study with Long-Term Radiostereometric Analysis Results
imageBackground: Recent short-term studies of total knee arthroplasty (TKA) have claimed improved clinical outcomes and implant survival when aiming to restore constitutional joint kinematics, as compared with neutral mechanical axis alignment. However, implant durability may be compromised when aligned in varus or valgus. With use of data pooled from 3 long-term radiostereometric analysis (RSA) studies, the aim of the present study was to assess the effects of coronal alignment on tibial component migration. Methods: Coronal alignment parameters from full-leg radiographs were measured and the constitutional leg alignment was determined for each patient. We evaluated the effect of the postoperative hip-knee-ankle angle, relative to both the mechanical axis and the constitutional alignment, on tibial component migration. In-range knees were defined as within ±3° of either the neutral mechanical axis or constitutional alignment of the patient. Analysis was performed with a linear mixed-effects model, corrected for study, age, sex, preoperative alignment, diagnosis, and body mass index. Results: A total of 85 cemented TKAs were included, of which 3 were revised for aseptic loosening and another 4 were considered loose. The median follow-up was 11 years. No loose tibial components were observed in mechanically in-range knees, whereas all loose tibial components were out of range. Mechanically varus knees showed the highest mean migration (maximum total point motion) of 1.55 mm (95% confidence interval [CI], 1.16 to 2.01 mm) after 5 years, compared with 1.07 mm (95% CI, 0.63 to 1.64 mm) and 0.77 mm (95% CI, 0.53 to 1.06 mm) for valgus and in-range knees, respectively (p < 0.001). In contrast, looking at constitutional alignment, loose tibial components were found among both constitutionally in-range and out-of-range knees. Mixed-model analysis showed comparable migration among constitutionally in-range, more-in-varus, and more-in-valgus aligned knees. Conclusions: Mechanically out-of-range alignment, especially mechanical varus, led to higher tibial component migration. However, matching the constitutional alignment of the patient did not preclude high implant migration. RSA trials randomizing different alignment techniques are needed to confirm the results of the present study. Level of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Τρίτη 16 Ιουλίου 2019

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


Ear, Nose & Throat Journal- Volume: 98, Number: 6 (July 2019) EditorialAccess to Quaternary Care:...
Ear, Nose & Throat Journal- Volume: 98, Number: 6 (July 2019)EditorialAccess to Quaternary Care: Studies Needed in OtolaryngologyRobert T. SataloffOtoscopic ClinicExophytic CholesteatomaMarcus L. Elias and Robert W. JyungRhinoscopic ClinicEndoscopic View of Fungus Ball in the Most Posterior Ethmoid Cell via the Supreme MeatusJae Hoon LeeLaryngoscopic ClinicsAn Unusual Hypopharyngeal Foreign Body Causing Dyspnea After VertebroplastySara Torretta, Alessandra Brevi, Claudio Guastella, Paolo Rampini, Marco...
Αλέξανδρος Γ. Σφακιανάκης
1m
Microsurgery Early View Online Version of Record before inclusion in an issue Microsurgery global...
MicrosurgeryEarly ViewOnline Version of Record before inclusion in an issueMicrosurgery global outreach to the developing world: Insights from VietnamAlbert H. Chao MDVersion of Record online: 12 July 2019Use of the subscapular system by maintaining unilateral decubitus placement without repositioning in microvascular free tissue transplantationAntonio J. Forte MD, PhD, Jeremie D. Oliver BS, BA, Matthew McRae MD, Cesar Colasante MD, Annica C. Eells BS, Andrew Watt MD, Rudolph Buntic MD, Gregory Buncke...
Αλέξανδρος Γ. Σφακιανάκης
1m
Documenta Ophthalmologica
Correlation between electroretinography, foveal anatomy and visual acuity in albinismAbstractBackgroundAlbinism patients have poor visual acuity in addition to hypopigmentation. Their foveal anatomy is abnormal, but correlation with function is incompletely understood. This study correlates retinal electrophysiology, visual acuity and optical coherence tomography (OCT) anatomy in albinism patients and compares with age-similar controls.MethodsInstitutional Review Board approval was obtained (IRB#...
Αλέξανδρος Γ. Σφακιανάκης
3m
Arteriovenous fistula presented with right ventricular failure, Farveh Vakilan, Fereshte Ghaderi,...
Arteriovenous fistula presented with right ventricular failure,Farveh Vakilan, Fereshte Ghaderi, Hoorak Poorzand, Mahmood Mohammadzadeh Shabestari, Arash GholobiArchives of Cardiovascular Imaging 2017 5(2):37-40Arteriovenous fistula could be traumatic with one manifestation as high-output heart failure. We present a 29-year-old male, referred for unexplained right-sided enlargement and the symptoms of right ventricular failure for 8 months ago. Considering right-sided dilatation, marked inferior...
Αλέξανδρος Γ. Σφακιανάκης
4m
Pregnancy complicated with severe aortic coarctation, Maryam Moshkani Farahani, Zahra Pour Jafar...
Pregnancy complicated with severe aortic coarctation,Maryam Moshkani Farahani, Zahra Pour JafarArchives of Cardiovascular Imaging 2017 5(2):35-36Coarctation of the aorta (COA) is a congenital disease with significant stenosis of the aorta which is associated with some complications such as hypertension. A 37-year-old pregnant woman was referred to our Cardiology Department for control of hypertension. She was in the 26th week of her gestation and she had another uneventful pregnancy 4 years ago....
Αλέξανδρος Γ. Σφακιανάκης
5m
Isolated congenital left ventricular diverticula: A rare cardiac anomaly, Nahid Rezaeian, Homa Najafi...
Isolated congenital left ventricular diverticula: A rare cardiac anomaly,Nahid Rezaeian, Homa NajafiArchives of Cardiovascular Imaging 2017 5(2):32-34Ventricular diverticula are a rare congenital abnormality characterized by synchronized contractility. Isolated diverticula mostly remain asymptomatic until adulthood. In this case report, we describe a 22-year-old woman with a history of pain in her arms and cold-induced skin discoloration. She was evaluated with echocardiography and cardiac magnetic...
Αλέξανδρος Γ. Σφακιανάκης
7m
Cardiac metastasis from a renal cell carcinoma without contiguous vena caval involvement, Azin Alizadeasl,...
Cardiac metastasis from a renal cell carcinoma without contiguous vena caval involvement,Azin Alizadeasl, Feridoun Noohi, Farnoosh Larti, Saeid Hosseini, Majid MalekiArchives of Cardiovascular Imaging 2017 5(2):30-31Tumors that involve the heart are more likely to represent metastatic disease than do primary cardiac neoplasms. Cardiac metastases from a renal cell carcinoma are rare and would be unique when there is no contiguous vena caval involvement such as the case that will be described here. Introduction Renal...
Αλέξανδρος Γ. Σφακιανάκης
7m
Cardiovascular Imaging
Left ventricular ejection fraction and mitral regurgitation assessment: A comparison study between echocardiography and angiographyAhmad Mirdamadi, Negah Tavakolifard, Ehsan EbrahimiArchives of Cardiovascular Imaging 2017 5(2):25-29Introduction: Measurement of the left ventricular ejection fraction (LVEF) is a common tool for evaluating the left ventricle (LV) systolic function. The aim of this study was to evaluate and compare the LVEF and mitral regurgitation (MR) severity as estimated by angiography...
Αλέξανδρος Γ. Σφακιανάκης
8m
Exercise Intensity Matters in Chronic Nonspecific Low Back Pain Rehabilitation, Introduction Exercise...
Exercise Intensity Matters in Chronic Nonspecific Low Back Pain Rehabilitation,Introduction Exercise therapy (ET) is advocated as a treatment for chronic nonspecific low back pain (CNSLBP). However, therapy effect sizes remain low. In other chronic disorders, training at higher intensity has resulted in greater improvements on both general health related and disease specific outcomes compared to lower intensity ET. Possibly, high intensity training also improves effect sizes in CNSLBP. Objective...
Αλέξανδρος Γ. Σφακιανάκης
9m
Feasibility of Two High-Intensity Interval Training Protocols in Cancer Survivors, Purpose High-intensity...
Feasibility of Two High-Intensity Interval Training Protocols in Cancer Survivors,Purpose High-intensity interval training (HIIT) is a time-efficient and promising tool for enhancing physical fitness. However, there is lack of research concerning safety and feasibility of HIIT in cancer survivors. Therefore, two different HIIT protocols were investigated in terms of safety, feasibility, and acute exercise responses. Methods Forty cancer survivors (20 breast and 20 prostate cancer survivors, 62.9±9.2...
Αλέξανδρος Γ. Σφακιανάκης
9m
Risk Estimates for Diabetes and Hypertension with Different Physical Activity Methods, Purpose To...
Risk Estimates for Diabetes and Hypertension with Different Physical Activity Methods,Purpose To estimate risks of incident Type 2 Diabetes (T2D) and Stage 2 and greater hypertension associated with self-reported and accelerometer-determined moderate-vigorous physical activity (MVPA) separately and adjusted for each other. Methods The sample included 2,291 black and white men and women, ages 38-50, in the CARDIA (Coronary Artery Risk Development in Young Adults) Fitness Study, conducted during the...
Αλέξανδρος Γ. Σφακιανάκης
10m
Medicine & Science in Sports & Exercise
Resistance Exercise-induced Changes in Muscle Metabolism are Load-dependentIntroduction Lower-load (LL), higher-repetition resistance exercise training (RET) can increase muscle mass similar degree as higher-load (HL), lower-repetition RET. However, little is known about how LL and HL RET modulate other aspects of the RET phenotype such as satellite cells, myonuclei, and mitochondrial proteins. We aimed to investigate changes in muscle mass, muscle strength, satellite cell activity, myonuclear addition,...
Αλέξανδρος Γ. Σφακιανάκης
10m
Journal of the European Academy of Dermatology and Venereology Accepted Articles Accepted, unedited...
Journal of the European Academy of Dermatology and VenereologyAccepted ArticlesAccepted, unedited articles published online and citable. The final edited and typeset Version of Record will appear in the future.Comparing Treatments for Basal Cell Carcinoma in Terms of Long‐term Treatment‐Failure: A Network Meta‐analysisTakeshi Fukumoto, Rie Fukumoto, Masahiro Oka, Nobuyuki HoritaFirst Published: 13 July 2019Incidence of cutaneous adverse events after exposure to tenofovir‐emtricitabine in HIV‐uninfected...
Αλέξανδρος Γ. Σφακιανάκης
11m
Journal of the European Academy of Dermatology and Venereology Early View Online Version of Record...
Journal of the European Academy of Dermatology and VenereologyEarly ViewOnline Version of Record before inclusion in an issue Open AccessComments on 'French guidelines on the use of systemic treatments for moderate‐to‐severe psoriasis in adults'C. Schuster, E. Perrin, E. RiedlVersion of Record online: 11 July 2019Review of autoimmune blistering diseases: the Pemphigoid diseasesB.S. Daniel, D.F. MurrellVersion of Record online: 11 July 2019Incidence and prevalence of psoriasis in Israel between 2011...
Αλέξανδρος Γ. Σφακιανάκης
11m
Supervised monthly doses of rifampicin-ofloxacin-minocycline (ROM)...........Rifampicin to be swallowed in front of a health worker (best on an empty stomach or at least 2 h after a meal; a total of 6 doses [6 months]) Ofloxacin to be swallowed in clinic once monthly – 6 doses Minocycline to be swallowed in clinic once monthly – 6 doses Dapsone once daily for 6 months. This treatment is likely to work even if the patient fails to take the daily doses of dapsone. More than three skin patches (MB) or if the skin smear was positive (if there are more than three patches, give this treatment even if the skin smear was negative): Give the same treatment as mentioned above, but also give clofazimine monthly to be swallowed in the clinic and a daily clofazimine dose as in
Suggested protocol for the management of leprosy by primary health-care cliniciansRajkumar RamasamyKC Patty Primary Health Centre, Kodaikanal, Tamil Nadu, IndiaDate of Web Publication16-Jul-2019Correspondence Address:Dr. Rajkumar RamasamyKC Patty Primary Health Centre, Kodaikanal, Tamil Nadu,IndiaSource of Support: None, Conflict of Interest: None  Abstract The new WHO guideline for the management of leprosy may not address all the grass roots realities of treating and preventing leprosy effectively...
Αλέξανδρος Γ. Σφακιανάκης
14m
Inferior vena cava filters – An overview, Sasank Kalipatnapu, Sunil Agarwal Department of Vascular...
Inferior vena cava filters – An overview,Sasank Kalipatnapu, Sunil AgarwalDepartment of Vascular Surgery, Christian Medical College, Vellore, Tamil Nadu, IndiaDate of Web Publication16-Jul-2019Correspondence Address:Dr. Sasank KalipatnapuDepartment of Vascular Surgery, Christian Medical College, Vellore - 632 002, Tamil NaduIndiaSource of Support: None, Conflict of Interest: None  Abstract Inferior Vena Cava Filters have been proven to prevent pulmonary embolism in patients with deep venous thrombosis...
Αλέξανδρος Γ. Σφακιανάκης
17m
Indications and contraindications for inferior vena cava filters*, Table 1: Types of filters
Indications and contraindications for inferior vena cava filters*,Table 1: Types of filters
Αλέξανδρος Γ. Σφακιανάκης
18m
Drug Dialogues. Curr Med Issues [serial online] 2019 [cited 2019 Jul 17];17:18-9. Available from: http://www.cmijournal.org/text.asp?2019/17/1/18/262826...
Drug Dialogues. Curr Med Issues [serial online] 2019 [cited 2019 Jul 17];17:18-9. Available from: http://www.cmijournal.org/text.asp?2019/17/1/18/262826
Αλέξανδρος Γ. Σφακιανάκης
19m
Medical Issues
Evaluation of discharge letters of patients who went against medical advice from the emergency department: A complete audit cycleKrishna Prasad, Linu SekharCurrent Medical Issues 2019 17(1):1-5Aim: The aim was to evaluate the discharge letters of patients who went "against medical advice" (AMA) from the emergency department (ED) before and after the introduction of a preformatted discharge letter in a tertiary care center in India. Methods: A prospective clinical audit of case sheets of 200 patients...
Αλέξανδρος Γ. Σφακιανάκης
20m
Morphometry of organization of middle meningeal artery through the analysis of bony canal in human's...
Morphometry of organization of middle meningeal artery through the analysis of bony canal in human's skull: A clinico-anatomical and embryological insightThittamaranahalli Muguregowda Honnegowda, Vineeth Dineshan, Ashwini KumarJournal of Craniovertebral Junction and Spine 2019 10(2):127-130Background: Middle meningeal artery (MMA) is the largest branch of the maxillary artery supplying meninges of the cranial cavity. The complexity of MMA development gives many opportunities for anatomical variation....
Αλέξανδρος Γ. Σφακιανάκης
21m
Posterior occiput-cervical fixation for metastasis to upper cervical spine Tarush Rustagi, Hazem Mashaly,...
Posterior occiput-cervical fixation for metastasis to upper cervical spineTarush Rustagi, Hazem Mashaly, Ehud MendelJournal of Craniovertebral Junction and Spine 2019 10(2):119-126Background: Metastasis to craniocervical area may result in instability manifesting as disabling pain, cranial nerve dysfunction, paralysis, or even death. Stabilization is required to prevent complications. Nonoperative treatment modalities are ineffective in providing stability and adequate pain relief. We present our...
Αλέξανδρος Γ. Σφακιανάκης
22m
Cervical rotation before and after hinge-door cervical laminoplasty for cervical spondylotic myelopathy...
Cervical rotation before and after hinge-door cervical laminoplasty for cervical spondylotic myelopathySachin A Borkar, Ravi Sreenivasan, Ravi Sharma, Sumit Sinha, S Leve Joseph, Ajay Garg, Shashank Sharad KaleJournal of Craniovertebral Junction and Spine 2019 10(2):114-118Background: Hinge-Door Cervical laminoplasty is commonly performed procedure in patients with cervical spondylotic myelopathy. Most available studies have established restriction of flexion and extension motion post laminoplasty...
Αλέξανδρος Γ. Σφακιανάκης
22m
Prevention of lumbar reherniation by the intraoperative use of a radiofrequency bipolar device: A case–control...
Prevention of lumbar reherniation by the intraoperative use of a radiofrequency bipolar device: A case–control studyGiovanni Grasso, Fabio Torregrossa, Alessandro LandiJournal of Craniovertebral Junction and Spine 2019 10(2):94-99Objective: The most common complication after lumbar discectomy is reherniation. Although many studies have investigated factors that may increase the reherniation risk, few are agreed upon all. It has been suggested that limited nucleus removal is associated with higher...
Αλέξανδρος Γ. Σφακιανάκης
22m
A limited unilateral transpedicular approach for anterior decompression of the thoracolumbar spinal...
A limited unilateral transpedicular approach for anterior decompression of the thoracolumbar spinal cord in elderly and high-risk patientsKhalid Alsaleh, Amjad AlduhaishJournal of Craniovertebral Junction and Spine 2019 10(2):88-93Background: Surgical treatment for elderly patients with thoracolumbar (TL) kyphosis and spinal cord (SC) compression presents significant challenges due to compression location, the amount of deformity, and patient's medical status might not permit full correction of the...
Αλέξανδρος Γ. Σφακιανάκης
23m
Torticollis and rotatory atlantoaxial dislocation: A clinical review Atul Goel Journal of Craniovertebral...
Torticollis and rotatory atlantoaxial dislocation: A clinical reviewAtul GoelJournal of Craniovertebral Junction and Spine 2019 10(2):77-87Rotatory atlantoaxial instability can manifest as an acute episode following subtle or minor injury or even following a gentle tap on head in young children and can manifest as a painless deformity of the head. Goel technique of direct surgical opening of the atlantoaxial facet joint, manual manipulation of the facets can lead to reduction of rotatory atlantoaxial...
Αλέξανδρος Γ. Σφακιανάκης
23m
Craniovertebral Junction and Spine
Is the term degenerative "spinal canal stenosis" a misnomer?Atul GoelJournal of Craniovertebral Junction and Spine 2019 10(2):75-76Torticollis and rotatory atlantoaxial dislocation: A clinical reviewAtul GoelJournal of Craniovertebral Junction and Spine 2019 10(2):77-87Rotatory atlantoaxial instability can manifest as an acute episode following subtle or minor injury or even following a gentle tap on head in young children and can manifest as a painless deformity of the head. Goel technique of direct...
Αλέξανδρος Γ. Σφακιανάκης
23m
Tropical Biomedicine
Development of new lateral-flow immunochromatographic strip using colloidal gold and mesoporous silica nanoparticles for rapid diagnosis of active schistosomiasisManal Kamel, Faten Salah, Zeinab Demerdash, Sara Maher, Shimaa Atta, Abeer Badr, Ahmed Afifi, Hanan El BazAsian Pacific Journal of Tropical Biomedicine 2019 9(8):315-322Objective: To develop a new sandwich based lateral flow immunochromatographic strip for rapid detection of circulating Schistosoma mansoni antigen in serum and urine samples...
Αλέξανδρος Γ. Σφακιανάκης
24m
Medical Research
'More, better, faster & sustained': Strengthen primary health care to advance universal health coverageChandrakant LahariyaIndian Journal of Medical Research 2019 149(4):433-436Emerging evidence that irritable bowel syndrome & functional dyspepsia are microbial diseasesNicholas J Talley, Marjorie M WalkerIndian Journal of Medical Research 2019 149(4):437-440Young-onset diabetes: An Indian perspectiveDeep Dutta, Soumitra GhoshIndian Journal of Medical Research 2019 149(4):441-442Clinical epidemiology...
Αλέξανδρος Γ. Σφακιανάκης
25m
Nephrology
Healthcare in India and violence against doctors: The missing linksSanjay Kumar AgarwalIndian Journal of Nephrology 2019 29(4):221-231Reset osmostat: Facts and controversiesJ Feder, JM Gomez, F Serra-Aguirre, CG MussoIndian Journal of Nephrology 2019 29(4):232-234Reset osmostat (RO) consists of a change in the normal plasma osmolality threshold (reduction or increase), which consequently induces chronic dysnatremia (hyponatremia or hypernatremia). Although the early papers on RO state that hyponatremic...
Αλέξανδρος Γ. Σφακιανάκης
26m
Anesthesia-Analgesia
Antiphospholipid Syndrome During Septic Shock: Hyper- or Hypocoagulability?: A Case ReportWe report the clinical case of a septic patient with antiphospholipid syndrome who developed ischemia in all 4 limbs, despite a normal systemic blood pressure. Prolonged coagulation times suggested a hemorrhagic diathesis, requiring transfusion of fresh-frozen plasma and discontinuation of heparin infusion. In contrast, the study of the viscoelastic properties of the clot by thromboelastography suggested an...
Αλέξανδρος Γ. Σφακιανάκης
27m
Efficacy and safety of sublingual dust mite drops in children with mono- or polysensitized allergic...
Efficacy and safety of sublingual dust mite drops in children with mono- or polysensitized allergic rhinitisAuthor links open overlay panelYao-zuZhangJuanLuoZi-hanWangJieWangDepartment of Otolaryngology-Head and Neck Surgery, The Affiliated Children Hospital of Xi'an Jiao Tong University, Shanxi, Xi'an 710003, ChinaReceived 4 May 2019, Available online 16 July 2019.Show lesshttps://doi.org/10.1016/j.amjoto.2019.07.010Get rights and contentAbstractObjectiveTo explore the efficacy and safety of sublingual...
Αλέξανδρος Γ. Σφακιανάκης
28m
Mycoses Volume 62, Issue 8Pages: 617-709 August 2019 ISSUE INFORMATION Issue Information Pages: 617-619...
MycosesVolume 62, Issue 8Pages: 617-709August 2019ISSUE INFORMATIONIssue InformationPages: 617-619 | First Published: 15 July 2019REVIEW ARTICLESCandida auris—the growing menace to global healthShabir A. Lone, Aijaz AhmadPages: 620-637 | First Published: 17 February 2019Vaginal yeast colonisation: From a potential harmless condition to clinical implications and management approaches—A literature reviewPanagiota Chatzivasileiou, Timoleon‐Achilleas VyzantiadisPages: 638-650 | First Published: 30 April...
Αλέξανδρος Γ. Σφακιανάκης
28m
Skin Research and Technology
Skin Research and TechnologyVolume 25, Issue 4Pages: 413-591July 2019ISSUE INFORMATIONISSUE INFORMATIONPages: 413 | First Published: 15 July 2019ORIGINAL ARTICLESInstrumental and sensory methodologies to characterize the residual film of topical products applied to skinGéraldine Savary, Laura Gilbert, Michel Grisel, Céline PicardPages: 415-423 | First Published: 15 February 2019Noninvasive analysis of skin proteins in healthy Chinese subjects using an Orbitrap Fusion Tribrid mass spectrometerJie...
Αλέξανδρος Γ. Σφακιανάκης
29m
Skin Research and Technology
Improved skin lesion edge detection method using Ant Colony OptimizationSkin Research and Technology, EarlyView. Classification and influencing factors analysis of facial skin color in Chinese populationSkin Research and Technology, EarlyView. Development of a new diaper dermatitis‐like reconstructed skin equivalent for testing children atopic dermatitis relieving cosmeticsSkin Research and Technology, EarlyView. Reflectance confocal microscopy and histological features of depigmentation after local...
Αλέξανδρος Γ. Σφακιανάκης
30m
Kavita Sivaramakrishnan. As the World Ages: Rethinking a Demographic Crisis,  Pat Thane  Alan I. Marcus, Malignant...
Kavita Sivaramakrishnan. As the World Ages: Rethinking a Demographic Crisis,  Pat Thane  Alan I. Marcus, Malignant Growth: Creating the Modern Cancer Research Establishment, 1875-1915  Kirsten E Gardner
Αλέξανδρος Γ. Σφακιανάκης
31m
Molecular typing of Streptococcus agalactiae isolates of serotype Ia from tilapia in southern China,  Youlu...
Molecular typing of Streptococcus agalactiae isolates of serotype Ia from tilapia in southern China,  Youlu Su; Chan Liu; Yiqin Deng; Changhong Cheng; Hongling Ma ... 
Αλέξανδρος Γ. Σφακιανάκης
32m
Pre-existing anti-neuraminidase antibodies are associated with shortened duration of influenza A (H1N1)pdm...
Pre-existing anti-neuraminidase antibodies are associated with shortened duration of influenza A (H1N1)pdm virus shedding and illness in naturally infected adults  Hannah E Maier ; Raffael Nachbagauer; Guillermina Kuan; Sophia Ng; Roger Lopez ...  National safety survey of animal-use commercial probiotics and its spillover effects from farm to human: an emerging threat to public health  Songzhe Fu; Qian Yang; Fenglan He; Ruiting Lan; Jingwei Hao ...  Graded Dalbavancin Challenge in a Patient with...
Αλέξανδρος Γ. Σφακιανάκης
32m
The Expectations and Challenges of Wildlife Disease Research in the Era of Genomics: Forecasting with...
The Expectations and Challenges of Wildlife Disease Research in the Era of Genomics: Forecasting with a Horizon Scan-like Exercise    Genomic signatures of selection along a climatic gradient in the northern range margin of the white-footed mouse (Peromyscus leucopus)  A Garcia-Elfring; R D H Barrett; V Millien
Αλέξανδρος Γ. Σφακιανάκης
32m
Pituitary
AcroVoice: the controversial values in reflecting acromegaly disease activityCorrection to: Rathke's cleft cysts: a 6-year experience of surgery vs. observation with comparative volumetric analysisThe original version of this article unfortunately contained errors in legend numbers of Figure 2 caption.Ectopic pituitary adenomas: common presentations of a rare entityAbstractPurposeEctopic pituitary adenomas (EPA) are rare tumors thought to arise from embryological remnants along the route of normal...
Αλέξανδρος Γ. Σφακιανάκης
33m
Rathke's cleft cysts: a 6-year experience of surgery vs. observation with comparative volumetric analysis...
Rathke's cleft cysts: a 6-year experience of surgery vs. observation with comparative volumetric analysisAbstractBackgroundRathke's cleft cysts (RCCs) are common sellar lesions. Their management remains controversial, particularly when small or asymptomatic. Herein we review a consecutive series of RCC patients managed with surgery or observation.MethodsAll patients with a new diagnosis of presumed RCC, based on MRI, from February 2012–March 2018 were retrospectively divided into observational and...
Αλέξανδρος Γ. Σφακιανάκης
33m
Role of gamma knife radiosurgery in the treatment of prolactinomas AbstractPurpose Stereotactic radiosurgery...
Role of gamma knife radiosurgery in the treatment of prolactinomasAbstractPurposeStereotactic radiosurgery is one of the treatment options for prolactinomas, the most commonly used being Gamma Knife Radiosurgery (GKRS). GKRS is indicated mainly in the treatment of dopamine agonist (DA)-resistant prolactinomas. In our study, we report on our experience in treating prolactinoma patients by GKRS.MethodsTwenty-eight patients were followed-up after GKRS for 26–195 months (median 140 months). Prior to...
Αλέξανδρος Γ. Σφακιανάκης
34m
Preoperative visual evoked potential in the prediction of visual outcome after pituitary macroadenomas...
Preoperative visual evoked potential in the prediction of visual outcome after pituitary macroadenomas surgeryAbstractObjectiveThe purpose of the present study is to investigate longitudinal changes in Visual evoked potential (VEP) parameters as an objective test after transsphenoidal surgery, its correlation with subjective tests and clinical value of VEP in the prediction of visual outcome.MethodsFifty patients with pituitary macroadenoma who underwent surgical removal of the tumor recruited in...
Αλέξανδρος Γ. Σφακιανάκης
34m
Ectopic pituitary adenomas: common presentations of a rare entity AbstractPurpose Ectopic pituitary...
Ectopic pituitary adenomas: common presentations of a rare entityAbstractPurposeEctopic pituitary adenomas (EPA) are rare tumors thought to arise from embryological remnants along the route of normal pituitary migration. Clinically, these tumors vary in hormonal activity and can exert mass effect based on location and size.MethodsWe performed a single-center retrospective analysis of patients with diagnosis of ectopic pituitary adenoma from 2001 to 2018.ResultsFive patients were identified with EPA:...
Αλέξανδρος Γ. Σφακιανάκης
34m
Development and Preliminary Findings of the Dizziness Symptom Profile Ear & Hearing...
Development and Preliminary Findings of the Dizziness Symptom ProfileEar & Hearing OnlineOfficial Journal of the American Auditory SocietyThe Power of Partnerships: Audiologist-Physician Collaboration Improves Patient CareThe Hearing JournalTeaching Written Expression to Students With Autism Spectrum Disorder and Complex Communication NeedsTopics In Language Disorders
Αλέξανδρος Γ. Σφακιανάκης
35m
Risk Factors For Childhood And Adult Primary Brain Tumors,  Quinn T Ostrom; Maral Adel Fahmideh; David...
Risk Factors For Childhood And Adult Primary Brain Tumors,  Quinn T Ostrom; Maral Adel Fahmideh; David J Cote; Ivo S Muskens ; Jeremy Michals Schraw...  CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse malignant IDH-mutant gliomas , Romain Appay; Caroline Dehais; Claude-Alain Maurage ; Agusti Alentorn; Catherine Carpentier
Αλέξανδρος Γ. Σφακιανάκης
36m
Verhandelte Stadt: Herrschaft und Gemeinde in der frühen Urbanisierung des Oberelsass vom 12. bis 14....
Verhandelte Stadt: Herrschaft und Gemeinde in der frühen Urbanisierung des Oberelsass vom 12. bis 14. Jahrhundert,  Tom Scott 
Αλέξανδρος Γ. Σφακιανάκης
36m
Les pratiques politiques dans les françaises d'Ancien Régime: Communauté, citoyenneté et localité,  Robert...
Les pratiques politiques dans les françaises d'Ancien Régime: Communauté, citoyenneté et localité,  Robert A Schneider  The Return of Alsace to France, 1918–1939  Detmar Klein  Fighting for France. Violence in Interwar French Politics  Martin Simpson
Αλέξανδρος Γ. Σφακιανάκης
37m
A Microhistory of the Global Empire of Cotton: Ivanovo, the 'Russian Manchester',  Alison K Smith  1989...
A Microhistory of the Global Empire of Cotton: Ivanovo, the 'Russian Manchester',  Alison K Smith  1989 at Thirty: A Recast Legacy  Paul Betts  Rejecting Catastrophe: the case of the Justinianic Plague  Lee Mordechai; Merle Eisenberg
Αλέξανδρος Γ. Σφακιανάκης
37m
Lasers in Medical Science
Correction to: Role of low-level laser therapy added to facial expression exercises in patients with idiopathic facial (Bell's) palsyThe published version contains a mistake in Figure 1. Below is the correct figure.Methodological correctness of a recent publication on pain entitled "Evaluating the effect of photobiomodulation with a 940-nm diode laser on post-operative pain in periodontal flap surgery"Laser-assisted hatching and clinical outcomes in frozen-thawed cleavage-embryo transfers of patients...
Αλέξανδρος Γ. Σφακιανάκης
38m
Diagnostic value of surveillance 18 F-fluorodeoxyglucose PET/CT for detecting recurrent esophageal...
Diagnostic value of surveillance 18 F-fluorodeoxyglucose PET/CT for detecting recurrent esophageal carcinoma after curative treatmentAbstractPurposeEsophageal carcinoma recurs within two years in approximately half of patients who receive curative treatment and is associated with poor survival. While 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a reliable method of detecting recurrent esophageal carcinoma, in most previous studies FDG PET/CT scans were...
Αλέξανδρος Γ. Σφακιανάκης
38m
Metabolic tumor burden on baseline 18 F-FDG PET/CT improves risk stratification in pediatric patients...
Metabolic tumor burden on baseline 18 F-FDG PET/CT improves risk stratification in pediatric patients with mature B-cell lymphomaAbstractPurposeIn order to better identify patients most at risk of treatment failure and disease progression in pediatric mature B-cell non-Hodgkin lymphoma (B-NHL), the prognostic role of metabolic tumor burden measured on baseline 18F-FDG PET/CT scan, including total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG), was investigated.MethodsPretreatment 18F-FDG...
Αλέξανδρος Γ. Σφακιανάκης
39m
Nuclear Medicine and Molecular Imaging
Eleanor Mantel, Janet S. Reddin, Gang Cheng, Abass Alavi (Eds): Nuclear Medicine Technology. Review Questions for the Board Examinations, Fifth Edition. Springer International Publishing AG, 2018. ISBN 978-3-319-62499-018 F-FDG PET/CT of sarcoidosis with extensive cutaneous and subcutaneous nodules: the snow leopard signAbdelhamid H Elgazzar, Ismet Sarikaya (Eds): Nuclear Medicine Companion. A Case-Based Practical Reference for Daily UseImaging of coronary flow capacity: is there a role for dynamic...
Αλέξανδρος Γ. Σφακιανάκης
39m
Cardiac Imaging   Left Atrial Fibrosis Assessed with Cardiac MRI in Patients with Paroxysmal and...
Cardiac Imaging Left Atrial Fibrosis Assessed with Cardiac MRI in Patients with Paroxysmal and Those with Persistent Atrial Fibrillation Focal left atrial fibrosis localized to the left inferior pulmonary vein antrum, the extent of left atrial fibrosis, and enlarged left atrial volume were independently associated with persistent atrial fibrillation at cardiac MRI.    Dong Kyu Lee, Jaemin Shim...Sung Ho Hwang Editorial: Searching for the Key to Foreseeing Left Atrial Fibrosis in Atrial Fibrillation:...
Αλέξανδρος Γ. Σφακιανάκης
40m
Biophysics
Biophysical characterization and molecular phylogeny of human KIN proteinAbstractThe DNA/RNA-binding KIN protein was discovered in 1989, and since then, it has been found to participate in several processes, e.g., as a transcription factor in bacteria, yeasts, and plants, in immunoglobulin isotype switching, and in the repair and resolution of double-strand breaks caused by ionizing radiation. However, the complete three-dimensional structure and biophysical properties of KIN remain important information...
Αλέξανδρος Γ. Σφακιανάκης
41m
Microbiology
RETRACTED ARTICLE: Phytobacter nematintestini sp. nov., isolated from the intestine of Caenorhabditis elegans and conferring resistance to Bacillus nematocida infectionThaumarchaeota affiliated with Soil Crenarchaeotic Group are prevalent in the alkaline soil of an alpine grassland in northwestern ChinaAbstractPurposeThaumarchaeota are key players within the global nitrogen cycle. Investigations of the Thaumarchaeota communities are important for an integrated understanding of nitrogen nutrient cycle...
Αλέξανδρος Γ. Σφακιανάκης
42m
  Tα ομορφότερα μικρά νησιά του Αιγαίου    Είναι μικρά, μοναχικά και πανέμορφα...
 Tα ομορφότερα μικρά νησιά του Αιγαίου   Είναι μικρά, μοναχικά και πανέμορφα...
Αλέξανδρος Γ. Σφακιανάκης
43m
  Η Μήλος θυμίζει κάτι... από Σελήνη, Η Μήλος είναι το εξωτικό νησί του Αιγαίου με ηφαιστειογενή...
 Η Μήλος θυμίζει κάτι... από Σελήνη,Η Μήλος είναι το εξωτικό νησί του Αιγαίου με ηφαιστειογενή πετρώματα, που χρωματίζουν τους βράχους των παραλίων ροζ, πορτοκαλί, κόκκινο και μαύρο.
Αλέξανδρος Γ. Σφακιανάκης
43m
Hematology
Familial case of hereditary Pelger-Huët anomalyDetection of Jordans' anomaly using compact-type automated hematology analyzerMacrophage elimination in bone marrow by dexamethasone palmitate is associated with successful engraftment in patients with hemophagocytic syndromeEpigenetic abnormalities and therapies for hematological malignanciesThe current state of human immunodeficiency virus-associated lymphoma in Japan: a nationwide retrospective study of the Japanese Society of Hematology Blood Disease...
Αλέξανδρος Γ. Σφακιανάκης
43m
Journal of Cosmetic Dermatology Early View Online Version of Record before inclusion in an issue ...
Journal of Cosmetic DermatologyEarly ViewOnline Version of Record before inclusion in an issue Open AccessIn vivo evaluation of the effectiveness of biocellulose facial masks as active delivery systems to skinPaola Perugini PhD, Mariella Bleve PhD, Renato Redondi PhD, Fabiola Cortinovis, Antonio Colpani PhDVersion of Record online: 13 July 2019Alopecia areata predictive score: A new trichoscopy‐based tool to predict treatment outcome in patients with patchy alopecia areataAnna Waśkiel‐Burnat MD,...
Αλέξανδρος Γ. Σφακιανάκης
44m
Pediatrics
Notice of Duplicate PublicationDetermination of Procalcitonin, C-Reactive Protein and White Blood Cell Levels to Diagnose Community-Acquired Pneumonia (CAP)Apple Peel Atresia with Isolated Fetal Ascites and Digit AnomaliesAssociation of Fecal Microflora with BronchiolitisRadCases Plus Q&A Pediatric Imaging: Richard B. Gunderman and Lisa R. Delaney (eds)Sialidosis Type 1: Giant SSEP and Novel MutationCarbon Monoxide Poisoning in a NeonateSerum Albumin and C-Reactive Protein as Predictors of Adverse...
Αλέξανδρος Γ. Σφακιανάκης
45m
Digital Humanities
Artificial imagination, imagine: new developments in digital scholarly editingOn edited archives and archived editionsAbstractBuilding on a longstanding terminological discussion in the field of textual scholarship, this essay explores the archival and editorial potential of the digital scholarly edition. Following Van Hulle and Eggert, the author argues that in the digital medium these traditionally distinct activities now find the space they need to complement and reinforce one another. By critically...
Αλέξανδρος Γ. Σφακιανάκης
45m
Cryptology
Generic Attacks on Hash CombinersAbstractHash combiners are a practical way to make cryptographic hash functions more tolerant to future attacks and compatible with existing infrastructure. A combiner combines two or more hash functions in a way that is hopefully more secure than each of the underlying hash functions, or at least remains secure as long as one of them is secure. Two classical hash combiners are the exclusive-or (XOR) combiner \( \mathcal {H}_1(M) \oplus \mathcal {H}_2(M) \) and the...
Αλέξανδρος Γ. Σφακιανάκης
46m
Biochemical Genetics
Analysis of Genetic Diversity and Development of a SCAR Marker for Green Tea ( Camellia sinensis ) Cultivars in Zhejiang Province: The Most Famous Green Tea-Producing Area in ChinaAbstractCamellia sinensis (L.) O. Kuntze is one of the most important non-alcoholic beverage crops in Asian and African countries. In recent years, many green tea cultivars have been released and played an important role in improving the production and quality of tea trees. The objectives of this study were to assess the...
Αλέξανδρος Γ. Σφακιανάκης
47m
Development Genes and Evolution
BioCell2XML : a novel tool for converting cell lineage data from SIMI BioCell to MaMuT (Fiji)AbstractComputer-assisted 4D manual cell tracking has been a valuable method for understanding spatial-temporal dynamics of embryogenesis (e.g., Stach & Anselmi BMC Biol, 13(113), 1–11 2015; Vellutini et al. BMC Biol, 15(33), 1–28 2017; Wolff et al. eLife, 7, e34410 2018) since the method was introduced in the late 1990s. Since two decades SIMI® BioCell (Schnabel et al. Dev Biol, 184, 234–265 1997), a...
Αλέξανδρος Γ. Σφακιανάκης
48m
Orthopaedics
Response to letter to the editor concerning "Orthopaedic surgery patients who use recreational marijuana have less pre-operative pain"Pre-operative virtual simulation and three-dimensional printing techniques for the surgical management of acetabular fracturesAbstractPurposeSurgical treatment of acetabular fractures with plate fixation is challenging for orthopaedic surgeons because of variations of the surface curvature and complex fracture patterns of the acetabulum. We present our experience with...
Αλέξανδρος Γ. Σφακιανάκης
48m
Environmental Contamination and Toxicology
Degradation of Bisphenol A in Natural and Artificial Marine and Freshwaters in TurkeyAbstractBisphenol A (BPA), one of the important synthetic chemicals, has been produced at high volumes since the 1960s. These chemicals are commonly detected in the marine and freshwater environments; however, their transformation in aquatic environments depends on many parameters. This study aims to investigate the degradation of BPA in marine and freshwaters under different conditions in terms of microbial degradation,...
Αλέξανδρος Γ. Σφακιανάκης
49m
Infrared, Millimeter, and Terahertz Waves
Planar Lens–Based Ultra-Wideband Dielectric Rod Waveguide Antenna for Tunable THz and Sub-THz Photomixer SourcesAbstractIn this manuscript, the use of dielectric rod waveguide antenna (DRW) with an embedded planar lens is proposed as a highly directional alternative to an electrically large hyper-hemispheric silicon lens for emission at millimeter and sub-millimeter wave frequencies. DRW antennas radiate properly if only the fundamental mode is excited to the structure. Since photomixer-based terahertz...
Αλέξανδρος Γ. Σφακιανάκης
50m
Perioperative Medicine, Genetic Analysis of Patients Who Experienced Awareness with Recall while under...
Perioperative Medicine,Genetic Analysis of Patients Who Experienced Awareness with Recall while under General AnesthesiaJamie W. Sleigh, M.D.; Kate Leslie, M.D.; Andrew J. Davidson, M.D.; David J. Amor, Ph.D.; Peter Diakumis, M.Bioinf.; Vesna Lukic, M.Sci.; Paul J. Lockhart, Ph.D.; Melanie Bahlo, Ph.D.Anesthesiology Published online July 15, 2019. doi:10.1097/ALN.0000000000002877SPECIAL ARTICLEMusings from an Unlikely Clinician–Scientist: 2018 American Society of Anesthesiologists Excellence in Research...
Αλέξανδρος Γ. Σφακιανάκης
51m
Dharma
Exchange and Transaction as a Form of Life and Meaning in the Logic of Tantric ConceptsAbstractThis essay examines conceptual metaphors from Śaiva-Śākta traditions of Hindu tantra. It explores how conceptual metaphors associated with heterodox ritual exchanges between humans and fierce divinities were employed and used to transform other ideas (bodily fluids, sacrificial products, sexualized symbols, celibacy, states of consciousness, ideas about kinship) to express a new kind of kinship or family...
Αλέξανδρος Γ. Σφακιανάκης
51m
Stem Cell Reviews and Reports
Effects of VEGF + Mesenchymal Stem Cells and Platelet-Rich Plasma on Inbred Rat Ovarian Functions in Cyclophosphamide-Induced Premature Ovarian Insufficiency ModelAbstractPremature ovarian insufficiency (POI), a fertility disorder affecting women under 40 years of age, is characterized by early loss of ovarian function. This study was aimed to maintain ovarian function in POI animal models by mesenchymal stem cells (MSCs) transplantation with/without the supplementation of platelet-rich plasma (PRP)....
Αλέξανδρος Γ. Σφακιανάκης
52m
Radiation Oncology
Letter to the Editor concerning "Re-irradiation in gynaecological cancers, present experiences and future hopes"Challenges in the re-irradiation of locally advanced head and neck cancers: outcomes and toxicitiesAbstractPurposeTo retrospectively review outcomes and toxicities for patients with recurrent head and neck cancer (HNC) undergoing re-irradiation (re-RT).MethodsRetrospective review of oncologic outcomes and toxicity data from patients who received head and neck (HN) re-RT with curative intent...
Αλέξανδρος Γ. Σφακιανάκης
52m
Medical and Biological Engineering
Robot Navigation Using a Brain Computer Interface Based on Motor ImageryAbstractAn interface between a human brain and a computer (or any external device) can be implemented for interchanging orders using a brain–computer interface (BCI) system. Motor imagery (MI), which represents human intention to execute actions or movements, can be captured and analyzed using brain signals such as electroencephalograms (EEGs). The present study focuses on a synchronous control system with a BCI based on MI for...
Αλέξανδρος Γ. Σφακιανάκης
52m
CNS Drugs
Temporal Trends and Predictors of Drug Utilization and Outcomes in First-Ever Stroke Patients: A Population-Based Study Using the Singapore Stroke RegistryAbstractIntroductionDrug utilization and outcomes research in multi-ethnic Asian stroke populations is lacking.ObjectivesOur objective was to examine temporal trends and predictors of drug utilization and outcomes in a multi-ethnic Asian stroke population.MethodsThis registry-based study included ischemic and hemorrhagic first-ever stroke patients...
Αλέξανδρος Γ. Σφακιανάκης
54m
Thyroid-Stimulating Hormone Reference Ranges for Preterm Infants, Dinushan C. Kaluarachchi, David...
Thyroid-Stimulating Hormone Reference Ranges for Preterm Infants,Dinushan C. Kaluarachchi, David B. Allen, Jens C. Eickhoff, Sandra J. Dawe and Mei W. BakerCommentaryAvoiding the Overdiagnosis of Congenital Hypothyroidism in Premature NewbornsFrancisca Grob and Guy Van Vliet
Αλέξανδρος Γ. Σφακιανάκης
56m
IN THIS ISSUE OF JAMA, Highlights Audio Summary: ICU Delirium and PTSD, Protocolized Sepsis Care and...
IN THIS ISSUE OF JAMA,HighlightsAudio Summary: ICU Delirium and PTSD, Protocolized Sepsis Care and Mortality, Time-To-Reperfusion and Stroke Outcomes, and moreORIGINAL INVESTIGATIONCaring for the Critically Ill PatientEffect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical TrialRegis Goulart Rosa, MD, PhD; Maicon Falavigna, MD, PhD; Daiana Barbosa da Silva, RN, MSc; et al.Earn CME creditEditorial: Psychological Consequences of...
Αλέξανδρος Γ. Σφακιανάκης
56m
Clinical Neuropharmacology
Factors Associated With Delirium in Surgical Intensive Care Unit Patients Treated With Supplemental Melatonin: A Case-Cohort StudyObjectives Intensive care unit (ICU) delirium is a common neuropsychiatric syndrome that confers significant morbidity and mortality. Melatonin is an endogenous neurohormone involved with regulating sleep-wake cycles and has been found to be disturbed in ICU delirium. We hypothesized that there are independent factors that predict delirium in a cohort of patients on melatonin...
Αλέξανδρος Γ. Σφακιανάκης
58m
Journal of Surgical Oncology Early View Online Version of Record before inclusion in an issue Race,...
Journal of Surgical OncologyEarly ViewOnline Version of Record before inclusion in an issueRace, ethnicity, and socioeconomic factors in cholangiocarcinoma: What is driving disparities in receipt of treatment?Rachel M. Lee MD, MSPH, Yuan Liu PhD, Adriana C. Gamboa MD, Mohammad Y. Zaidi MD, MS, David A. Kooby MD, FACS, Mihir M. Shah MD, Kenneth Cardona MD, FACS, Maria C. Russell MD, FACS, Shishir K. Maithel MD, FACSVersion of Record online: 13 July 2019A prediction model for lymph node metastasis...
Αλέξανδρος Γ. Σφακιανάκης
58m
Pathological Gambling Associated With Aripiprazole      Objectives Pathological gambling can be potentiated...
Pathological Gambling Associated With Aripiprazole      Objectives Pathological gambling can be potentiated by treatment with dopamine agonists. Aripiprazole, bearing a partial agonist activity at dopamine D2 and D3 receptors, has also been linked to such a behavioral aberration, usually on subjects predisposed with tendency of impulsive or addictive behaviors. Methods Review of patient's medical records and literature review. Results Two young patients' pathological gambling emerged simply due to...
Αλέξανδρος Γ. Σφακιανάκης
59m
Sertraline-Related Amenorrhea in an Adolescent  Amenorrhea is one of the clinical consequences of hyperprolactinemia....
Sertraline-Related Amenorrhea in an Adolescent Amenorrhea is one of the clinical consequences of hyperprolactinemia. Although symptomatic hyperprolactinemia is among the well-described adverse reactions of antipsychotic agents, it may also be reported with the use of selective serotonin reuptake inhibitors. Hereby, we present a case of sertraline-related hyperprolactinemic amenorrhea in an adolescent. Amenorrhea occurred 2 months after starting sertraline, and menstrual cycle restored after stopping...
Αλέξανδρος Γ. Σφακιανάκης
59m
Levetiracetam-Related Mania-Like Symptoms: An Adolescent Case Levetiracetam is an antiepileptic agent...
Levetiracetam-Related Mania-Like Symptoms: An Adolescent CaseLevetiracetam is an antiepileptic agent that is used for partial and generalized epilepsy. Although it is well tolerated in most cases, behavioral and nonbehavioral adverse effects may be observed. Among behavioral symptoms, depression, hostility, and agitation have been frequently reported. However, mania or mania-like symptoms are relatively rare, especially in children and adolescents. Hereby, we report mania-like symptoms with levetiracetam...
Αλέξανδρος Γ. Σφακιανάκης
1h
Drug-Induced Parkinsonism Manifesting as Gait Freezing in a Patient With Traumatic Brain Injury: A...
Drug-Induced Parkinsonism Manifesting as Gait Freezing in a Patient With Traumatic Brain Injury: A Case ReportBackground Among the neuropsychiatric complications commonly induced by traumatic brain injury (TBI), behavioral disorders, such as agitation and aggression, can hinder neurological recovery and deteriorate rehabilitation outcomes. Pharmacological treatment for behavioral disorders might be beneficial but could lead to drug-induced parkinsonism. We report a case of a patient with drug-induced...
Αλέξανδρος Γ. Σφακιανάκης
1h
Therapeutic Drug Monitoring
Official International Association for Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Development and Validation of Dried Blood Spot–Based Methods for Therapeutic Drug MonitoringAbstract: Dried blood spot (DBS) analysis has been introduced more and more into clinical practice to facilitate Therapeutic Drug Monitoring (TDM). To assure the quality of bioanalytical methods, the design, development and validation needs to fit the intended use. Current validation requirements, described...
Αλέξανδρος Γ. Σφακιανάκης
1h
Allergic Contact Dermatitis Due to Benzoyl Peroxide From an Unlikely Source Adelman, Madeline, BS*;...
Allergic Contact Dermatitis Due to Benzoyl Peroxide From an Unlikely SourceAdelman, Madeline, BS*; Mohammad, Tasneem, MD†; Kerr, Holly, MD†Dermatitis: May/June 2019 - Volume 30 - Issue 3 - p 230–231doi: 10.1097/DER.0000000000000470PEARLS & ZEBRASBenzoyl peroxide is effective for reducing the number and severity of acne lesions. It has a bactericidal effect on Cutibacterium acnes bacteria associated with acne and does not induce antibiotic resistance.[11][12] It may be combined with salicylic...
Αλέξανδρος Γ. Σφακιανάκης
1h
Nursing Research
Maintaining and Improving Psychological Well-BeingNo abstract availableMediating Effects of Social Support on Depression and Suicidal Ideation in Older Korean Adults With Hypertension Who Live AloneBackground: Older adults who live alone are less physically and emotionally healthy and report higher levels of depression relative to those who do not live alone. Suicide is the most problematic health issue reported by older adults who live alone. In particular, vulnerable older adults who live alone...
Αλέξανδρος Γ. Σφακιανάκης
1h
Bathing Additives for Atopic Dermatitis — A Systematic Review Bathing additives are regularly used...
Bathing Additives for Atopic Dermatitis — A Systematic ReviewBathing additives are regularly used for a range of inflammatory dermatoses that affect a large body surface area. Emerging evidence demonstrates that certain bathing additives have anti-inflammatory, skin barrier repair, antimicrobial, and antioxidative properties, all pertinent to atopic dermatitis. This review summarizes the mechanism and effects of Dead Sea salt, hard water, commercial baby cleansers, oatmeal, rice, and natural oils...
Αλέξανδρος Γ. Σφακιανάκης
1h
Poison Ivy, Oak, and Sumac Dermatitis: What Is Known and What Is New? Poison ivy, poison oak, and poison...
Poison Ivy, Oak, and Sumac Dermatitis: What Is Known and What Is New?Poison ivy, poison oak, and poison sumac are the most common causes of clinically diagnosed allergic contact dermatitis in North America. Approximately 50% to 75% of the US adult population is clinically sensitive to poison ivy, oak, and sumac. We reviewed the botany and history of these plants; urushiol chemistry and pathophysiology, clinical features, and the prevalence of allergic contact dermatitis caused by these plants; and...
Αλέξανδρος Γ. Σφακιανάκης
1h
Dermatitis
SELF-ASSESSMENTNo abstract availablePoison Ivy, Oak, and Sumac Dermatitis: What Is Known and What Is New?Poison ivy, poison oak, and poison sumac are the most common causes of clinically diagnosed allergic contact dermatitis in North America. Approximately 50% to 75% of the US adult population is clinically sensitive to poison ivy, oak, and sumac. We reviewed the botany and history of these plants; urushiol chemistry and pathophysiology, clinical features, and the prevalence of allergic contact dermatitis...
Αλέξανδρος Γ. Σφακιανάκης
1h
Supraglottic Airway Rescue After Failed Fiberoptic Intubation in a Patient With Osteogenesis Imperfecta:...
Supraglottic Airway Rescue After Failed Fiberoptic Intubation in a Patient With Osteogenesis Imperfecta: A Case ReportWe describe the management of a pregnant patient with osteogenesis imperfecta with a history of numerous fractures, severe scoliosis, and anticipated difficult airway. Her pregnancy was complicated by progressive shortness of breath and a fetal diagnosis of osteogenesis imperfecta. Spine anatomy precluded neuraxial anesthesia. Cesarean delivery was performed under general anesthesia...
Αλέξανδρος Γ. Σφακιανάκης
1h
Urgent Complex Intraoperative Reintubation in a Known Difficult Airway After Endotracheal Tube Damage:...
Urgent Complex Intraoperative Reintubation in a Known Difficult Airway After Endotracheal Tube Damage: A Case ReportTreacher Collins syndrome is an inherited disorder resulting in maldevelopment of the first and second branchial arches. Patients have complex orofacial anatomy often requiring airway interventions from birth. A 17-year-old boy with Treacher Collins syndrome and history of difficult ventilation and intubation presented for elective maxillofacial reconstruction. After uneventful awake...
Αλέξανδρος Γ. Σφακιανάκης
1h
Retrieval of a Esophageal pH Monitoring Probe Dislodged Into the Laryngopharynx: A Case Report Esophageal...
Retrieval of a Esophageal pH Monitoring Probe Dislodged Into the Laryngopharynx: A Case ReportEsophageal pH monitoring via wireless probes is used to evaluate chest pain and atypical symptoms and diagnose gastroesophageal reflux. These probes are commonly placed during esophagogastroduodenoscopy performed by gastroenterologists in an ambulatory anesthesia setting. Dislodgment and aspiration of these probes can cause morbidity, require surgical removal, and involve the anesthesia provider in prolonged...
Αλέξανδρος Γ. Σφακιανάκης
1h
Rare electrosurgical complications in tonsillectomy: Analysis of national adverse event reporting Alisa...
Rare electrosurgical complications in tonsillectomy: Analysis of national adverse event reportingAlisa Yamasaki MD  Neil Bhattacharyya MD, FACSFirst published: 11 July 2019 https://doi.org/10.1002/lary.28181Editor's Note: This Manuscript was accepted for publication on June 24, 2019.Presented as an oral presentation at the Triological Society Combined Sections Meeting 2019, Coronado, California, U.S.A., January 24–26, 2019.The authors have no funding, financial relationships, or conflicts of interest...
Αλέξανδρος Γ. Σφακιανάκης
1h
Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy, Avigeet Gupta BS  Sina...
Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy,Avigeet Gupta BS  Sina Koochakzadeh BS  David M. Neskey MD, MSCR  Shaun A. Nguyen MD, MA  Eric J. Lentsch MDFirst published: 10 July 2019 https://doi.org/10.1002/lary.28183Editor's Note: This Manuscript was accepted for publication on June 24, 2019.The authors have no funding, financial relationships, or conflicts of interest to disclose.Read the full textePDFPDFTOOLS SHAREAbstractObjectives/HypothesisCarcinosarcomas represent...
Αλέξανδρος Γ. Σφακιανάκης
1h
Cornelia de lange manifestations in otolaryngology: A systematic review and meta‐analysis, Mathieu Bergeron...
Cornelia de lange manifestations in otolaryngology: A systematic review and meta‐analysis,Mathieu Bergeron BPharm, MD, FRCSC  Katherine Chang BS  Stacey L. Ishman MD, MPHFirst published: 13 July 2019 https://doi.org/10.1002/lary.28169Editor's Note: This Manuscript was accepted for publication on June 13, 2019.The authors have no funding, financial relationships, or conflicts of interest to disclose.Read the full textePDFPDFTOOLS SHAREAbstractObjectivesCornelia de Lange syndrome (CdLS) is a rare genetic...
Αλέξανδρος Γ. Σφακιανάκης
1h
Anaesthesia
Retrieval of a Esophageal pH Monitoring Probe Dislodged Into the Laryngopharynx: A Case ReportEsophageal pH monitoring via wireless probes is used to evaluate chest pain and atypical symptoms and diagnose gastroesophageal reflux. These probes are commonly placed during esophagogastroduodenoscopy performed by gastroenterologists in an ambulatory anesthesia setting. Dislodgment and aspiration of these probes can cause morbidity, require surgical removal, and involve the anesthesia provider in prolonged...
Αλέξανδρος Γ. Σφακιανάκης
1h
The Laryngoscope Early View Online Version of Record before inclusion in an issue Pattern and severity...
The LaryngoscopeEarly ViewOnline Version of Record before inclusion in an issuePattern and severity of transverse sinus stenosis in patients with pulsatile tinnitus associated with sigmoid sinus wall anomaliesDaniel Hewes MD, Robert Morales MD, Prashant Raghavan MBBS, David J. Eisenman MDVersion of Record online: 13 July 2019Cornelia de lange manifestations in otolaryngology: A systematic review and meta‐analysisMathieu Bergeron BPharm, MD, FRCSC, Katherine Chang BS, Stacey L. Ishman MD, MPHVersion...
Αλέξανδρος Γ. Σφακιανάκης
1h
Oncology - Spandidos Publications
Suicide gene‑armed measles vaccine virus for the treatment of AMLStefanie Maurer, Helmut R. Salih, Irina Smirnow, Ulrich M. Lauer, Susanne BerchtoldView Abstract ❯SOX4 regulates invasion of bladder cancer cells via repression of WNT5aJosue D. Moran, Hannah H. Kim, Zhenghong Li, Carlos S. MorenoView Abstract ❯Prognostic significance of VHL, HIF1A, HIF2A, VEGFA and p53 expression in patients with clear‑cell renal cell carcinoma treated with sunitinib as first‑line treatmentPiotr M. Wierzbicki, Jakub...
Αλέξανδρος Γ. Σφακιανάκης
1h
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Microbial EcologyTaurine Is a Major Carbon and Energy Source for Marine Prokaryotes in the North Atlantic Ocean off the Iberian PeninsulaAbstractTaurine, an amino acid-like compound, acts as an osmostress protectant in many marine metazoans and algae and is released via various processes into the oceanic dissolved organic matter pool. Taurine transporters are widespread among members of the marine prokaryotic community, tentatively indicating that taurine might be an important substrate for prokaryotes...
Αλέξανδρος Γ. Σφακιανάκης
1d
Blood Cells, Molecules, and Diseases
Predictors of autoimmune hemolytic anemia in beta-thalassemia patients with underlying red blood cells autoantibodiesPublication date: November 2019Source: Blood Cells, Molecules, and Diseases, Volume 79Author(s): Monia Ben Khaled, Monia Ouederni, Nessrine Sahli, Nawel Dhouib, Ahmed Ben Abdelaziz, Samia Rekaya, Ridha Kouki, Houda Kaabi, Hmida Slama, Fethi Mellouli, Mohamed BejaouiAbstractIn beta-thalassemia patients, erythrocyte autoantibodies can remain silent or lead to Autoimmune Hemolytic Anemia...
Αλέξανδρος Γ. Σφακιανάκης
1d
Clinical Nuclear Medicine
Unexpected Lymphatic Drainage of the Treated BreastThis case highlights the use of lymphoscintigraphy with SPECT/CT in patients with previous chest and/or axillary surgery. A 67-year-old woman with a history of left breast carcinoma treated with lumpectomy and radiotherapy, and a second lumpectomy of the ipsilateral breast for a second breast carcinoma, underwent a lymphoscintigraphy for a new left breast lesion. Planar images visualized an alternative lymphatic drainage to the contralateral axilla...
Αλέξανδρος Γ. Σφακιανάκης
1d
Applied Immunohistochemistry & Molecular Morphology
Comparison of Dako HercepTest and Ventana PATHWAY Anti-HER2 (4B5) Tests and Their Correlation With Fluorescent In Situ Hybridization in Breast CarcinomaObjectives: We compared the performance of two Food and Drug Administration–approved HER2 immunohistochemistry (IHC) tests: HercepTest (Dako) and PATHWAY anti-HER2 (4B5) (Ventana). Materials and Methods: In total, 180 invasive breast carcinomas previously tested by both HercepTest and fluorescent in situ hybridization (FISH) were retested with 4B5....
Αλέξανδρος Γ. Σφακιανάκης
1d
Coronary Artery Disease
Beneficial effect of ticagrelor on microvascular perfusion in patients with ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary interventionBackground Ticagrelor significantly reduced the incidence of death, myocardial infarction, and stent thrombosis in patients with ST-segment elevation myocardial infarction (STEMI) intended for reperfusion with a primary percutaneous coronary intervention (pPCI). However, the effects of this drug on microvascular perfusion in...
Αλέξανδρος Γ. Σφακιανάκης
1d
Diseases of the Colon & Rectum
Drs Julio Garcia-Aguilar and Emina Huang: Colorectal Surgeons Advancing the Science of Colorectal DiseasesNo abstract availableEvaluation and Management of Enterocutaneous FistulaCase Summary: A 36-year-old woman presents with an abscess at her midline wound 4 weeks following an ileocecectomy for Crohn's disease. After the abscess is incised, there is purulent drainage followed by the drainage of enteric contents; the output is 750 mL per 24 hours.Expert Commentary on the Management of Enterocutaneous...
Αλέξανδρος Γ. Σφακιανάκης
1d
Pancreas
The 49th Annual Meeting of the American Pancreatic Association in Collaboration With the International Association of PancreatologyNo abstract availableNext-Generation Sequencing in Pancreatic CancerPancreatic ductal adenocarcinoma (PDAC) is lethal, and the majority of patients present with locally advanced or metastatic disease that is not amenable to cure. Thus, with surgical resection being the only curative modality, it is critical that disease is identified at an earlier stage to allow the appropriate...
Αλέξανδρος Γ. Σφακιανάκης
1d
NeuroReport
Cellular, Molecular and Developmental NeuroscienceOffline beats online transcranial direct current stimulation timing influences on working memoryFriehs, Maximilian A.; Frings, ChristianNeuroReport. 30(12):795-799, August 14, 2019.AbstractFavorites PDF Get Content & PermissionsThe n-back task is an established measure of an individual's working memory. In this task, participants have to continuously update their working memory to react to a stimulus correctly. For the verbal n-back task in particular,...
Αλέξανδρος Γ. Σφακιανάκης
1d
Shock
 Collapse Box Clinical Science AspectsAssociation of Sex With Clinical Outcome in Critically Ill Sepsis Patients A Retrospective Analysis of the Large Clinical Database MIMIC-IIIXu, Jinghong; Tong, Li; Yao, Jiyou; MoreShock. 52(2):146-151, August 2019.AbstractFavoritesPDF Get Content & PermissionsIntroduction:The objective of our study was to explore the association between sex and clinical outcome in sepsis patients in a large, diverse population.Materials and Methods:We analyzed 6,134 adult...
Αλέξανδρος Γ. Σφακιανάκης
1d
Pediatric Infectious Diseases
Multidrug-resistant Gram-negative Bacterial Bloodstream Infections in Children's Hospitals in Japan, 2010–2017Background: The risk factors of multidrug-resistant (MDR) Gram-negative bacilli (GNB) bloodstream infection (BSI) are not yet known in children. Our aim was to evaluate risk factors and outcomes associated with MDR GNB BSI in children. Methods: Patients with GNB BSI were enrolled between April 2010 and March 2017 at 8 children's hospitals in Japan. Clinical and microbiologic data were collected...
Αλέξανδρος Γ. Σφακιανάκης
1d
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
SCCMPediatric Critical Care MedicineCritical Care Explorations, https://journals.lww.com/ccmjournal/toc/publishahead,...SCCMPediatric Critical Care MedicineCritical Care Explorations,https://journals.lww.com/ccmjournal/toc/publishahead,Online First - Last Updated: July 15, 2019The editors of this journal are pleased to offer electronic publication of accepted papers prior to print publication. These papers can be cited using the date of access and the unique DOI number. Any final changes in manuscripts...
Αλέξανδρος Γ. Σφακιανάκης
1d