Homoeopathy

Popularity, safety and quality of homoeopathic medicines Raj K Manchanda Indian Journal of Research in Homoeopathy 2018 12(4):191-193

An open-label pilot study to identify the usefulness of adjuvant homoeopathic medicines in the treatment of cerebral stroke patients Aslam Abbas, Md Shahid Ali, Hima Bindu Ponnam, Divya Taneja, Anil Khurana, Chaturbhuja Nayak, Anil Santapur Indian Journal of Research in Homoeopathy 2018 12(4):194-201 Background: Stroke, the third leading cause for neurological morbidity and mortality has a global annual incidence of 0.2–2.5/1000 population. The clinical sequelae of stroke are often devastating with hemiparesis, depression, walking difficulties and aphasia. It is essential to take measures halting the progression of stroke. Homoeopathic literature mentions many medicines for stroke. Till a pilot study was undertaken to study the usefulness of Homoeopathy as an adjuvant therapy to standard conventional care in stroke patients. Materials and Methods: An open-label pilot study was conducted at Princess Durru Shehvar Children's and General Hospital, Hyderabad, in coordination with Extension Clinical Research Unit of Central Council for Research in Homoeopathy. Fifty patients presenting with episodes of cerebral stroke of the different period were assessed by the National Institute of Health Stroke Scale (NIHSS) Score, prior homoeopathic treatment and after 6 months of treatment. Results: Of 50 patients, 10 patients had stroke more than 1 year and suffering with sequelae, 27 patients had stroke episode between 1 month and 1 year and 13 patients had a stroke episode within 4 weeks. The reduction in NIHSS score after 6 months of treatment was statistically significant in all three groups. The useful medicines found were Causticum (n = 11), Arnica montana (n = 7), Nux vomica (n = 6), Lycopodium (n = 6) and Lachesis (n = 3). Neither patient had worsening signs nor any new infarcts during the study. Conclusion: This pilot study showed encouraging results. Further randomised control trials are suggested to evaluate the efficacy of homoeopathic medicines in stroke.

Homoeopathic drug dilutions of Thuja occidentalis attenuate complete Freund's adjuvant-induced arthritis in Wistar rats Sachin S Patil, Umesh B Mahajan, Sameer N Goyal, Sateesh Belemkar, Chandragouda R Patil Indian Journal of Research in Homoeopathy 2018 12(4):202-211 Context: Thuja occidentalis is prescribed in Homoeopathy in treating rheumatoid arthritis. We speculated the anti-arthritic mechanism of Homoeopathic dilutions of Thuja occidentalis against the complete Freund's adjuvant (CFA)-induced arthritis in rats. Materials and Methods: Arthritis was induced (n = 28) by subplantar injection of 0.1 ml CFA in the right hind paw of rats. The oral dose of crude Thuja occidentalis was 30 mg/kg/b. i. d and that of Homoeopathic dilutions was 0.1 ml/b. i. d. Orally administered diclofenac at 5 mg/kg/day served as a standard. The treatments continued for 24 days. The severity of arthritis was determined weekly as rise in paw volume, mechanical allodynia and changes in body weight. On the 25th day, X-ray imaging of the arthritic paws was recorded, and the biopsy samples extracted from the paws were subjected to the estimation of pro-inflammatory cytokines and histological evaluations. Results: Thuja occidentalis Homoeopathic dilutions and its crude form protected rats against the CFA-induced arthritic lesions. The mother tincture, 6cH, 30cH and 200cH dilutions of Thuja occidentalis significantly reduced the CFA-induced rise in paw volume, reduced the mechanical allodynia and also reduced the levels of interleukin (IL) IL-1, IL-6 and tumour necrosis factor alpha in paw tissue. CFA-induced articular changes, oedema, cellular infiltrations and cartilage damage were reduced by Thuja occidentalis dilutions. The radiological images indicated that Thuja occidentalis treatment reduced the CFA-induced joint swelling, bone erosion and joint space narrowing. Conclusion: Our findings substantiate the anti-arthritic effects of Thuja occidentalis Homoeopathic dilutions against CFA-induced arthritis and indicate that Homoeopathic dilutions of Thuja occidentalis, particularly 6cH dilution, exert more potent anti-arthritic effects than its crude form.

Chemoprofiling of homoeopathic drug Holarrhena antidysenterica L. Rakhi Mishra, Manoj Kumar, Binit Dwivedi, BS Arya, Renu Arya, Anil Khurana, Raj K Manchanda Indian Journal of Research in Homoeopathy 2018 12(4):212-219 Background: Chemoprofiling of homoeopathic drug/tincture (HT) represents a comprehensive approach for evaluation of quality, purity, safety and efficacy of HT. This paper reflects the chemoprofiling of Homoeopathic drug Holarrhena antidysentrica L. Objective: The objective of this study is to standardise Holarrhena antidysenterica mother tincture by taking the samples from four different sources: Dr D. P. Rastogi, CRI (H) Noida (A) and three from market (labelled as B, C and D). Materials and Methods: The authentic sample of bark of Holarrhena antidysenterica supplied by the Centre of Medicinal Plants Research in Homoeopathy, Emerald, Tamil Nadu, India was used to prepare the mother tincture (as per the Homoeopathic Pharmacopoeia of India). The solvents used throughout the study, namely, ethanol, high-pressure liquid chromatography water, cyclohexane, chloromethane and diethylamine, were of analytical grade purity (MERCK Ltd.). Physicochemical properties, ultraviolet (UV) spectroscopy and high-performance thin-layer chromatography (HPTLC) chemoprofile of raw drug and mother tinctures were standardised and compared with market samples. Results: The present study reveals the moisture content (14.40%), total ash (4.65%), alcohol (18.0%), water extractive values (16.0%), total solids (1.47%), weight/ml (0.92 g) and alcohol content (60.6%). In UV spectroscopy, λmaxvalues were observed at 228 and 278 nm in HT. HPTLC analysis of in-house HT (A) and three market samples (B, C, D) was performed by using cyclohexane: chloromethane: diethylamine (7:3:1, v/v/v) as mobile phase. Under UV light (254, 366 nm) and in the presence of visualising agent Dragendroff, bands of active constituent were observed in all the four samples. However, excess amount of active constituents were found in in-house HT (a) rather than the market samples (B, C and D). Conclusion: The present physicochemical and phytochemical data may be considered as pharmacopoeia standards for the homoeopathic drug Holarrhema antidysentrica L.

World Integrated Medicine Forum 2017: A feedback survey analysis Anupriya Chaudhary, Harleen Kaur, Jyoti Sachdeva, Mohua Dutta, Anil Khurana, Robbert van Haselen, Raj K Manchanda Indian Journal of Research in Homoeopathy 2018 12(4):220-230 Introduction: The first-of-its-kind World Integrated Medicine Forum (WIMF) on the regulation of homoeopathic medicinal products (HMPs) which was attended by various stakeholders from 23 countries witnessed rigorous discussions to strengthen existing regulatory framework of homoeopathic medicines in the world, as well as to bring harmony within the Homoeopathy market for drug manufacture standards including pharmacopoeial convergence. Materials and Methods: A feedback questionnaire was shared with the participants through SurveyMonkey online platform to seek their opinion about the Forum, obtain their country-specific views about regulations of HMPs, to evaluate the extent to which the Forum could meet its objectives and also to identify areas of improvements which may be taken note for organising a future WIMF. Results: Sixty-one percent participants from 18 countries returned the survey. Analysis of the responses revealed a group consensus about the remarkable organisation of the Forum, its usefulness from a national perspective, etc. The questions could also fetch insight about country-specific reforms that are required in the availability and regulations of HMPs. All the respondents who took the survey recommended a next Forum on the same lines, out of which 92% said they would recommend it to other colleagues. Conclusion: Homoeopathy is a widely recognised and accepted system worldwide. Based on its increasing demand, a harmonised regulatory system for homeopathic medicines must be developed to ensure good quality of HMPs, and this can be achieved through cooperative interactions among various stakeholders, both nationally and globally. A Forum such as this, at least once every 2 years, can provide the right push on this front.

Effect of individualised Homoeopathy in the treatment of infertility Suraia Parveen, Himadri Bhaumik Indian Journal of Research in Homoeopathy 2018 12(4):231-239 A 37-year-old woman, being married for 6 years, presented to the homoeopathic outpatient department, after treatment of infertility by a gynaecologist for few years. She had a past history of emergency ovarian cystectomy for endometriosis 1 year after her marriage. Her subsequent infertility workup revealed hydrosalpinx with one-sided tubal block along with the evidence of poor ovarian reserve. Her husband's semen analysis was normal and was advised for donor-ovum in vitro fertilisation. At this point, she was treated with constitutional homoeopathic medicine following the miasmatic analysis with the holistic concept of Homoeopathy over 6 months. Treatment started with Silicea and later switched to Syphilinum. She conceived normally after that and subsequently delivered a healthy baby at full term. This case shows the positive role of classical homoeopathic treatment on subfertility.

Republication-predatory journals: A downside on research and hampering the impact and relevance of scientific outcome NC Jain, Ginu Suhail Khan Indian Journal of Research in Homoeopathy 2018 12(4):240-247 The advancement of medical knowledge is quintessentially based on the authentic and reliable scientific research and publications. This is in addition to the recently mandated requirement of original research publications in indexed journals to ensure career progression in academic/medical institutions; thus, the need for ‘publications’ in scientific medical scholarly journals has increased substantially. On the other hand, this has given an unparalleled rise in the number of standalone journals and publishers ‘predatory’ is the term, who are ready to process the manuscripts on priority with almost guaranteed publication, at a cost, but having no credibility to the research being published. To foster awareness creation among students at the post-graduate level and for faculty of medical colleges and research institutions, it has become very important to avoid these predatory journals. It is high time that the thinking among researchers of ‘publish or perish’ be changed to ‘Publish and Flourish’ by adopting stringent measures which have evolved over time to curtail this birch of predatory publishing. Researchers should now take the road less travelled. This review article aims to highlight all the relevant and important points about the threats posed by predatory journals and also suggests possible ways to overcome them. Republished with permission from: Jain NC, Khan GS. Predatory Journals: A Downside on Research and Hampering the Impact and Relevance of Scientific Outcome. RUHS J Health Sci 2018;3:99-105.

Obituary of Dr. Upma Bagai Sukhbir Kaur Indian Journal of Research in Homoeopathy 2018 12(4):248-249 Dr. Upma Bagai left for her heavenly abode on 8 September 2018. At the time of her untimely demise, she was serving as Professor and Chairperson, Department of Zoology, Panjab University, Chandigarh.

Erratum: Homoeopathic treatment for lower urinary tract symptoms in men with benign prostatic hyperplasia: An open label randomised multicentric placebo-controlled clinical trial Indian Journal of Research in Homoeopathy 2018 12(4):250-250

Cancers, Vol. 11, Pages 200: Continuous Separation of Circulating Tumor Cells from Whole Blood Using a Slanted Weir Microfluidic Device

Cancers, Vol. 11, Pages 200: Continuous Separation of Circulating Tumor Cells from Whole Blood Using a Slanted Weir Microfluidic Device

Cancers doi: 10.3390/cancers11020200

Authors: Yoon Lee Ra Gwon Lee Kim Yoo Sul Kim Kim Park Lee Lee Choi Lee

The separation of circulating tumor cells (CTCs) from the peripheral blood is an important issue that has been highlighted because of their high clinical potential. However, techniques that depend solely on tumor-specific surface molecules or just the larger size of CTCs are limited by tumor heterogeneity. Here, we present a slanted weir microfluidic device that utilizes the size and deformability of CTCs to separate them from the unprocessed whole blood. By testing its ability using a highly invasive breast cancer cell line, our device achieved a 97% separation efficiency, while showing an 8-log depletion of erythrocytes and 5.6-log depletion of leukocytes. We also developed an image analysis tool that was able to characterize the various morphologies and differing deformability of the separating cells. From the results, we believe our system possesses a high potential for liquid biopsy, aiding future cancer research.

http://bit.ly/2Gkc5hk

Cancers, Vol. 11, Pages 202: SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro

Cancers, Vol. 11, Pages 202: SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro

Cancers doi: 10.3390/cancers11020202

Authors: Conny Tümmler Gianina Dumitriu Malin Wickström Peter Coopman Andrey Valkov Per Kogner John Inge Johnsen Ugo Moens Baldur Sveinbjörnsson

Neuroblastoma is a malignancy arising from the developing sympathetic nervous system and the most common and deadly cancer of infancy. New therapies are needed to improve the prognosis for high-risk patients and to reduce toxicity and late effects. Spleen tyrosine kinase (SYK) has previously been identified as a promising drug target in various inflammatory diseases and cancers but has so far not been extensively studied as a potential therapeutic target in neuroblastoma. In this study, we observed elevated SYK gene expression in neuroblastoma compared to neural crest and benign neurofibroma. While SYK protein was detected in the majority of examined neuroblastoma tissues it was less frequently observed in neuroblastoma cell lines. Depletion of SYK by siRNA and the use of small molecule SYK inhibitors significantly reduced the cell viability of neuroblastoma cell lines expressing SYK protein. Moreover, SYK inhibition decreased ERK1/2 and Akt phosphorylation. The SYK inhibitor BAY 613606 enhanced the effect of different chemotherapeutic drugs. Transient expression of a constitutive active SYK variant increased the viability of neuroblastoma cells independent of endogenous SYK levels. Collectively, our findings suggest that targeting SYK in combination with conventional chemotherapy should be further evaluated as a treatment option in neuroblastoma.

http://bit.ly/2I3hD13

Cancers, Vol. 11, Pages 201: The Role of Molecular Profiling to Predict the Response to Immune Checkpoint Inhibitors in Lung Cancer

Cancers, Vol. 11, Pages 201: The Role of Molecular Profiling to Predict the Response to Immune Checkpoint Inhibitors in Lung Cancer

Cancers doi: 10.3390/cancers11020201

Authors: Kaderbhaï Tharin Ghiringhelli

Immune checkpoint inhibitors radically changed the treatment of patients with non-small cell lung cancer (NSCLC). However, only one-quarter of patients benefit from these new therapies when used as monotherapy. The assessment of Program Death Ligand-1 (PD-L1) tumor expression by immunohistochemistry is used to select potential responder patients, but this not an optimal marker since it does not predict the absence of anti PD-1 efficacy. Despite this shortcoming, PD-L1 remains the gold standard biomarker in many studies and the only biomarker available for clinicians. In addition to histological markers, transcriptomic and exome analyses have revealed potential biomarkers requiring further confirmation. Recently, tumor mutational burden has emerged as a good surrogate marker of outcome. In this review we will detail current knowledge on DNA and RNA related biomarkers.

http://bit.ly/2GgIGod

Changing Autonomy in Operative Experience Through UK General Surgery Training: A National Cohort Study

Objectives: To determine the operative experience of UK general surgery trainees and assess the changing procedural supervision and acquisition of competency assessments through the course of training. Background: Competency assessment is changing with concepts of trainee autonomy decisions (termed entrustment decisions) being introduced to surgical training. Methods: Data from the Intercollegiate Surgical Curriculum Programme and the eLogbook databases for all UK General Surgery trainees registered from August 1, 2007 who had completed training were used. Total and index procedures (IP) were counted and variation by year of training assessed. Recorded supervision codes and competency assessment outcomes for IPs were assessed by year of training. Results: We identified 311 trainees with complete data. Appendicectomy was the most frequently undertaken IP during first year of training [mean procedures (mp) = 26] and emergency laparotomy during final year of training (mp = 27). The proportion of all IPs recorded as unsupervised increased through training (P

http://bit.ly/2WRnj1x

Enhanced Recovery in Patients With Diabetes: Is it Time for a Moratorium on Use of Preoperative Carbohydrate Beverages?

No abstract available

http://bit.ly/2RK2xND

Use of Prophylactic Mesh When Creating a Colostomy Does Not Prevent Parastomal Hernia: A Randomized Controlled Trial—STOMAMESH

Objective: The aim of this study was to determine whether parastomal hernia (PSH) rate can be reduced by using synthetic mesh in the sublay position when constructing permanent end colostomy. The secondary aim was to investigate possible side-effects of the mesh. Background: Prevention of PSH is important as it often causes discomfort and leakage from stoma dressing. Different methods of prevention have been tried, including several mesh techniques. The incidence of PSH is high; up to 78%. Methods: Randomized controlled double-blinded multicenter trial. Patients undergoing open colorectal surgery, including creation of a permanent end colostomy, were randomized into 2 groups, with and without mesh. A lightweight polypropylene mesh was placed around the colostomy in the sublay position. Follow up after 1 month and 1 year. Computerized tomography and clinical examination were used to detect PSH at the 1-year follow up. Data were analyzed on an intention-to-treat basis. Results: After 1 year, 211 of 232 patients underwent clinical examination and 198 radiologic assessments. Operation time was 36 minutes longer in the mesh arm. No difference in rate of PSH was revealed in the analyses of clinical (P = 0.866) and radiologic (P = 0.748) data. There was no significant difference in perioperative complications. Conclusions: The use of reinforcing mesh does not alter the rate of PSH. No difference in complication rate was seen between the 2 arms. Based on these results, the prophylactic use of mesh to prevent PSH cannot be recommended.

http://bit.ly/2WNuwzE