NK-cell enteropathy: a case report with ten years of indolent clinical behavior

Abstract

NK-cell enteropathy is a recently described clinically indolent condition characterized by atypical NK-cell infiltrates in the gastrointestinal mucosa that mimics malignant lymphoma. We report the case of a 69-year-old female who clinically had long-standing abdominal pain and recurrent mucosal ulcerations associated with atypical NK-cell infiltrates. The clinical, morphologic, and immunophenotypic findings in this case were diagnostic of NK-cell enteropathy. Review of the patient's prior biopsies demonstrated that this persisted without clinical progression for ten years—confirming the clinical indolent course. Recognition of NK-cell enteropathy is important to avoid over-diagnosing this benign condition as an aggressive lymphoma.

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iSepsis – Sepsis 3.0- Flogging a dead horse!

qSOFA: Fails Once Again.

EMCrit Project by Paul Marik.

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A Selection of Abstracts Presented at the 44th Annual Conference of the Anatomical Society of Southern Africa (ASSA), May 8–11, 2016, Bloem Spa Hotel and Conference Centre, Bloemfontein, Free State, South Africa

In memory of Professor Willie Vorster who was a long-standing member of ASSA and served on the Council for many years. He was a devoted teacher of Anatomy and Embryology at various tertiary institutions in South Africa, and the founding member of the School of Medicine at the University of Namibia where he served as the first Professor in Anatomy.

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A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

A method for determination of permeability in a membrane insert system for multi-well plates and in silico parameter optimization for the calculation of diffusion coefficients using simulation are presented.

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A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

We describe a method to measure the activation of Fc-mediated effector functions by antibodies that target the influenza virus hemagglutinin. This assay can also be adapted to assess the ability of monoclonal antibodies or polyclonal sera targeting other viral surface glycoproteins to induce Fc-mediated immunity.

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Impact of pulsed xenon ultraviolet disinfection on surface contamination in a hospital facility’s expressed human milk feed preparation area

Expressed human milk (EHM) feed preparation areas represent a potential source of unintentional nosocomial infection. Daily disinfection of environmental surfaces remains an essential intervention to mitigate ...

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Seroprevalence of dengue IgG antibodies in symptomatic and asymptomatic individuals three years after an outbreak in Zhejiang Province, China

Cross-reacting antibodies enhanced dengue infection in humans and antibody dependent enhancement (ADE) have been proposed as early mechanisms underlying DHF/DSS. However, the duration of dengue IgG antibodies ...

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